Hepatoprotective Effect of the Methanolic Extract of whole Plant of Borreria articularis on Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats

The hepatoprotective activity of methanolic extract of Borreria articularis ( L.F) F.N. W illams: ( Rubiaceae ) at doses of 250 mg/kg and 500 mg/kg were evaluated by carbon tetrachloride (CCl ₄ ) intoxication in rats. The toxic group which received 25% CCl ₄ in olive o il (1 ml/kg ) per oral (p.o), alone exhi bited significant incre ase in serum ALT , AS T , ALP , TB l evels. It also exhibited significant (P<0. 001) decre ase in TP and ALB l evels. The groups received pretreatment of Borreria articularis at a dose of 250 and 500 mg/kg b.w.p.o. had reduced the AST, ALT, ALP and TB levels and the effects were comp ar ed with standard drug (Silymarin 100 mg/kg b .w.p. o).The total protein (TP) and albumin (ALB) levels we re signifi cantly increased in the animals received pretre atment of the extract at the moderate and higher dose l evels and the histop athological studi es also supported the protective effect of the extract.