Asian Journal of Pharmaceutical Research and Health Care

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The hepatoprotective effect of the alcohol extract of Capparis sepiaria Linn. (Capparaceae) stem against carbon tetrachloride (CCl 4 )-induced toxicity was studied in albino rats. The rats were given daily pretreatment with alcohol extract of C. sepiaria (100 mg/kg) and the standard silymarin (25 mg/kg) orally for 7 days. The toxicant used on 7 th day was CCl 4 at a dose of 1.25 ml/kg as 1:1 mixture with olive oil. The extract produced significant (p<0.01) reduction in the elevated levels of aspartate transaminase (AST), alanine transaminase (ALT), total bilirubin (TB) and rise of decreased total protein level when compared with the toxic control.

Keywords

Hepatoprotective, Capparis sepiaria , Carbon Tetrachloride, Silymarin.
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