Asian Journal of Pharmaceutical Research and Health Care

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Triacontanol Improves Production of Anticancer Alkaloids in Catharanthus roseus L.


Affiliations
1 Department of Botany, Plant Physiology Section, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
2 Department of Biology, University of Tabuk, Tabuk - 71491, Saudi Arabia
3 Department of Botany, Malda College, Malda, West Bengal, India
4 Botany Section, Women's College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
 

Catharanthus roseus (L.) G. Don is a medicinal plant that bears indole alkaloids used in cancer chemotherapy. The anticancer alkaloids, viz. vinblastine and vincristine, are mainly present in leaves of C. roseus. As there is high demand and low yield of these alkaloids in C. roseus, alternative ways to improve alkaloid production are needed. Hence, it was hypothesized that Triacontanol (TRIA), a potent plant growth promoting substance for various medicinal and agricultural crops, would improve alkaloid production in C. roseus. A pot culture experiment was carried out and the effects of TRIA on production of total alkaloids including anticancer alkaloids were evaluated at 120 and 150 days after planting. Four concentrations of TRIA [10-0 (Control) 10-7, 10-6 and 10-5 M] were tested through leaf spraying. TRIA at 10-6 M significantly increased yield attributes. As compared to the control (10-0 M), leaf-applied TRIA at 10-6 M improved the production (yield) of anticancerous alkaloids vinblastine (+71.6%) and vincristine (+73.1%) and caused the highest content and yield of vindoline.


Keywords

Catharanthus roseus, Triacontanol (TRIA), Vinblastine, Vincristine, Vindoline Alkaloids
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  • Triacontanol Improves Production of Anticancer Alkaloids in Catharanthus roseus L.

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Authors

M. Naeem
Department of Botany, Plant Physiology Section, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
Abid Ali Ansari
Department of Biology, University of Tabuk, Tabuk - 71491, Saudi Arabia
Tariq Aftab
Department of Botany, Plant Physiology Section, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
M. Masidur Alam
Department of Botany, Malda College, Malda, West Bengal, India
M. Masroor A. Khan
Department of Botany, Plant Physiology Section, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
Moin Uddin
Botany Section, Women's College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

Abstract


Catharanthus roseus (L.) G. Don is a medicinal plant that bears indole alkaloids used in cancer chemotherapy. The anticancer alkaloids, viz. vinblastine and vincristine, are mainly present in leaves of C. roseus. As there is high demand and low yield of these alkaloids in C. roseus, alternative ways to improve alkaloid production are needed. Hence, it was hypothesized that Triacontanol (TRIA), a potent plant growth promoting substance for various medicinal and agricultural crops, would improve alkaloid production in C. roseus. A pot culture experiment was carried out and the effects of TRIA on production of total alkaloids including anticancer alkaloids were evaluated at 120 and 150 days after planting. Four concentrations of TRIA [10-0 (Control) 10-7, 10-6 and 10-5 M] were tested through leaf spraying. TRIA at 10-6 M significantly increased yield attributes. As compared to the control (10-0 M), leaf-applied TRIA at 10-6 M improved the production (yield) of anticancerous alkaloids vinblastine (+71.6%) and vincristine (+73.1%) and caused the highest content and yield of vindoline.


Keywords


Catharanthus roseus, Triacontanol (TRIA), Vinblastine, Vincristine, Vindoline Alkaloids

References





DOI: https://doi.org/10.18311/ajprhc%2F2019%2F23541