Asian Journal of Pharmaceutical Research and Health Care

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Drugs-Inducing Hepatotoxicity


Affiliations
1 Department of Pharmacology and Toxicology, University of Tabuk, Saudi Arabia
2 Department of Pharmaceutics, Northern Border University,, Saudi Arabia
3 Department of Pharmacology and Toxicology, Northern Border University, Saudi Arabia
 

The liver is the largest solid organ, the largest gland, and one of the most vital organs that functions as a center for the metabolism of nutrients and excretion of waste metabolites. Hepatotoxicity is becoming a leading cause of death worldwide and its prevalence is increasing exponentially, there are several causes behind hepatotoxicity such as administration of acetaminophen that induced hepatotoxicity through the excessive formation of the toxic metabolite N-acetyl-para-benzoquinone imine (NAPQI). Drug-induced liver injury may account for approximately 10% of all cases of acute hepatitis, 5% of all hospital admissions, and 50% of all acute liver failures. Remarkably, more than 75% of cases of idiosyncratic drug reactions result in liver transplantation or death. This review will help researchers to understand the hepatotoxicity mechanism of common drugs that have a hepatotoxic effect.

Keywords

Acetaminophen, Anti-Tuberculosis Drugs, Hepatotoxic Drugs, Hepatotoxicity, Phenytoin.
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  • Drugs-Inducing Hepatotoxicity

Abstract Views: 356  |  PDF Views: 131

Authors

Mohammed M. Alshehri
Department of Pharmacology and Toxicology, University of Tabuk, Saudi Arabia
Muhammad Wahab Amjad
Department of Pharmaceutics, Northern Border University,, Saudi Arabia
Mahmoud M. E. Mudawi
Department of Pharmacology and Toxicology, Northern Border University, Saudi Arabia

Abstract


The liver is the largest solid organ, the largest gland, and one of the most vital organs that functions as a center for the metabolism of nutrients and excretion of waste metabolites. Hepatotoxicity is becoming a leading cause of death worldwide and its prevalence is increasing exponentially, there are several causes behind hepatotoxicity such as administration of acetaminophen that induced hepatotoxicity through the excessive formation of the toxic metabolite N-acetyl-para-benzoquinone imine (NAPQI). Drug-induced liver injury may account for approximately 10% of all cases of acute hepatitis, 5% of all hospital admissions, and 50% of all acute liver failures. Remarkably, more than 75% of cases of idiosyncratic drug reactions result in liver transplantation or death. This review will help researchers to understand the hepatotoxicity mechanism of common drugs that have a hepatotoxic effect.

Keywords


Acetaminophen, Anti-Tuberculosis Drugs, Hepatotoxic Drugs, Hepatotoxicity, Phenytoin.

References





DOI: https://doi.org/10.18311/ajprhc%2F2020%2F25518