The Asian Journal of Animal Science

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Antimicrobial Resistance:A Global Public Health and Economic Concern


Affiliations
1 Department of Veterinary Public Health and Epidemiology, College of Veterinary Science and Animal Husbandry, Acharya Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya (U.P.), India
     

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Antibiotic resistance is a global concern that is present in every country. Infections caused by drug-resistant bacteria increases the risk of clinical outcomes and death of patients and consume more health-care resources.Antimicrobial resistance (AMR) increases the cost of health care, long time period stays in hospitals and requirement of more intensive care. The success of major surgery and cancer chemotherapy would be compromised without effective antimicrobials.The cost of health care for patients with resistant infections is higher due to longer duration of illness, additional tests and use of more expensive drugs. AMR occurs naturally over time, usually through genetic changes. However, the misuse and overuse of antimicrobials accelerates this process. In many places, antibiotics are overused and misused in animals and humans and often given without professional supervision. Other factors that encourage the spread of antimicrobial resistance include inadequate sanitary conditions, inappropriate food-handling and poor infection control. Antimicrobial resistance (AMR) including multidrug resistance (MDR), is on the rise among many micro-organisms in healthcare facilities as well as in community. Antimicrobial resistance in infections caused by Escherichia coli, Klebsiellapneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) has posed a significant impact on health and economic burden across the world. AMR is an increasingly serious threat to global public health that requires action across all government sectors and society. The measures can limit the development and spread of antimicrobial resistance include hygiene and sanitation, vaccination, sustainable animal husbandry practices, health education, epidemiological surveillance and research, national action plan, optimization of use of antimicrobials, development of the economic case for sustainable investment, judicious use of antimicrobials and co-operation of international organizations/agencies.

Keywords

Antimicrobial, Resistance, Impact, Prevention, Control.
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  • Ahmad, M. and Khan, A.U. (2019). Global economic impact of antibiotic resistance: A review. J. Global Antimicrobial Resistance, 19: 313-316. https://doi.org/10.1016/j.jgar.2019. 05.024.

  • Aslam, B., Wang, W., Imran, M., Arshad, Khurshid, M., Muzammil, S., Rasool, M.H., Nisar, M.A., Alvi1, R.F., Aslam, M.A., Qamar, M.U. Salamat, M.K.F. and Baloch, Z. (2018). Antibiotic resistance: a rundown of a global crisis. Infection & Drug Resistance,11 : 1645–1658.

  • Centre for Disease Control and Prevention (2013). Antibiotic resistance threats in the United States, US Department of Human and Health Services, Centre for Disease Control and prevention, 23, 2013.

  • Davies, J. and Davies, D. (2010).Origins and evolution of antibiotic resistance.Microbiol. Mol. Biol. Rev.,74 (3): 417-433.

  • Dugassa, J. and Shukuri, N. (2017). Review on antibiotic resistance and its mechanism of development. J. Health, Medicine & Nursing, 1 (3) : 11-17.

  • European Medicines Agency and European Centre for Disease Prevention and Control (2009). Joint Technical Report. The bacterial challenge: time to react. European Centre for Disease Prevention and Control, 2009.EMEA. doc. ref. EMEA/576176/2009.

  • Humphrey, T.J., Slater, E., McAlpine, K., Rowbury, R.J. and Gilbert, R.J. (1995). Salmonella enteritidis phage type 4 isolates more tolerant of heat, acid, or hydrogen peroxide also survive longer on surfaces. Appl. Environ.Microbiol., 61: 3161-3164.

  • Lan, R., Reeves, P.R. and Octavia, S. (2009). Population structure, origins and evolution of major Salmonella enterica clones. Infect. Genet.Evol., 9: 996-1005.

  • Marshall, B.M. and Levy, S.B. (2011). Food animals and antimicrobials: impacts on human health. Clin. Microbiol. Rev., 24 (4) : 718-733.

  • Michael, C.A., Dominey-Howes, D. and Labbate, M. (2014).The antimicrobial resistance crisis: causes, consequences, and management. Front Public Health, 2 : 145.

  • Nathan, C. (2004). Antibiotics at the crossroads.Nature, 431 (7011) : 899-902.

  • Singer, A.C., Shaw, H., Rhodes, V. and Hart, A. (2016). Review of antimicrobial resistance in the environment and its relevance to environmental regulators. Front. Microbiol.,7 : 1728.

  • Spellberg, B., Srinivasan, A. and Chambers, H.F. (2016). New societal approaches to empowering antibiotic stewardship. JAMA, 315 (12) : 1229-1230.

  • Van Boeckel, T.P., Brower, C. and Gilbert, M. (2015).Global trends in antimicrobial use in food animals. Proc. Natl. Acad. Sci. U S A., 112 (18) : 5649-5654.

  • World Health Organization (2014). Antimicrobial Resistance: Global Report on Surveillance. WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland.

  • World Health Organization. (2018).World Health Organization.Tuberculosis. Key Facts.18 September, 2018.

  • WEBLIOGRAPHY........

  • World Health Organization (2008). Report of the second meeting of the WHO Task Force on XDR-TB, WHO Headquarters, Geneva, Switzerland, 9-10 April 2008. World Health Organization. https://apps.who.int/iris/handle/10665/84515.

  • World Health Organization (2012). The evolving threat of antimicrobial resistance: options for action. World Health Organization. https://apps.who.int/iris/handle/10665/44812.

  • World Health Organization (2015). Worldwide country situation analysis: response to antimicrobial resistance. World Health Organization. https://apps.who.int/iris/handle/10665/163468.


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  • Antimicrobial Resistance:A Global Public Health and Economic Concern

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Authors

Chandra Shekhar
Department of Veterinary Public Health and Epidemiology, College of Veterinary Science and Animal Husbandry, Acharya Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya (U.P.), India

Abstract


Antibiotic resistance is a global concern that is present in every country. Infections caused by drug-resistant bacteria increases the risk of clinical outcomes and death of patients and consume more health-care resources.Antimicrobial resistance (AMR) increases the cost of health care, long time period stays in hospitals and requirement of more intensive care. The success of major surgery and cancer chemotherapy would be compromised without effective antimicrobials.The cost of health care for patients with resistant infections is higher due to longer duration of illness, additional tests and use of more expensive drugs. AMR occurs naturally over time, usually through genetic changes. However, the misuse and overuse of antimicrobials accelerates this process. In many places, antibiotics are overused and misused in animals and humans and often given without professional supervision. Other factors that encourage the spread of antimicrobial resistance include inadequate sanitary conditions, inappropriate food-handling and poor infection control. Antimicrobial resistance (AMR) including multidrug resistance (MDR), is on the rise among many micro-organisms in healthcare facilities as well as in community. Antimicrobial resistance in infections caused by Escherichia coli, Klebsiellapneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) has posed a significant impact on health and economic burden across the world. AMR is an increasingly serious threat to global public health that requires action across all government sectors and society. The measures can limit the development and spread of antimicrobial resistance include hygiene and sanitation, vaccination, sustainable animal husbandry practices, health education, epidemiological surveillance and research, national action plan, optimization of use of antimicrobials, development of the economic case for sustainable investment, judicious use of antimicrobials and co-operation of international organizations/agencies.

Keywords


Antimicrobial, Resistance, Impact, Prevention, Control.

References