Nephroprotective Effect of Solanum nigrum L. on Gentamicin Induced Toxicity in Male Albino Rats

Solanum nigrum L., is a medicinal herb that has been used as nephroprotective agent in Chinese medicine. In this study, the protective effect of Solanum nigrum L., (SN) against gentamicin-induced nephrotoxicity in rats was evaluated. Nephrotoxicity was induced in Wistar rats by intraperitoneal administration of gentamicin 100 mg/kg/day for eight days. Effect of concurrent administration of fresh juice extract of Solanum nigrum at a dose of 100 mg/kg/day given by oral route was determined using serum creatinine, AST, ALT, blood urea, ALP, ACP, reduced glutathione, catalase, glutathione peroxidase and protein as indicators of kidney damage. The fresh juice extract of Solanum nigrum significantly protected rat kidneys from gentamicin-induced nephrotoxicity by normalizing the alterations in biochemical parameters. Hence, it can be concluded that the extract possesses significant nephroprotective activity.