Nephroprotective and Antioxidant Activities of Tephrosia purpurea L. on Paracetamol and Gentamicin Induced Albino Rats

Nephroprotective and antioxidant activities of Tephrosia purpurea have been evaluated against paracetamol and gentamicin induced renal damage in male albino rats. Paracetamol (200mg/kg) and gentamicin (40mg/kg) induced renal damage was well manifested by significant increase in the levels of ALT, AST, ALP, urea, creatinine, sodium in serum. On the other hand, the of levels potassium, protein, albumin, enzymatic and non enzymatic antioxidants were lowered. The oral administration of varying doses of ethanolic extract of Tephrosia purpurea (5,10 and 15 mg/kg) for the period of 7 days reversed these altered parameters to normal levels indicating the antioxidative and nephroprotective efficacy of Tephrosia purpurea L. against paracetamol and gentamicin induced renal injury.