Asian Journal of Bio Science

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In Vitro Cytotoxicity of Extracts and Fractions from Aerial Parts of Calotropis procera Against CNS Cancer Cell Line


Affiliations
1 School of Biotechnology, University of Jammu, Jammu (J & K), India
2 Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar (Punjab), India
3 Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi (J & K), India
     

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Calotropis procera (Ait.) R.Br., a popular medicinal species in Indian system of medicine, is widely used for the treatment of various diseases. In the present investigation the cytotoxicity of the three extracts and their fractions from aerial parts of Calotropis procera was evaluated against central nervous system (SNB-78) human cancer cell line. The results showed that hydro-alcohloic extract has more potential at three different concentrations of 10, 30 and 100 μg/ml, among all the three extracts viz., alcoholic, hydro-alcoholic and aqueous extracts. On evaluation of the various fractions, n-butanol fraction of both hydro-alcoholic and alcoholic extracts had shown antiproliferative activity against human cancer cell line of central nervous system (SNB-78) at three different concentrations of 10 and 30 μg/ml. Aqueous extract was found to be least active.

Keywords

Calotropis Procera, Aerial Parts, Extracts, Fractions, Cytotoxicity, Human Cancer Cell Line.
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  • In Vitro Cytotoxicity of Extracts and Fractions from Aerial Parts of Calotropis procera Against CNS Cancer Cell Line

Abstract Views: 480  |  PDF Views: 0

Authors

Madhulika Bhagat
School of Biotechnology, University of Jammu, Jammu (J & K), India
Jatinder Singh Arora
Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar (Punjab), India
Ajit Kumar Saxena
Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi (J & K), India

Abstract


Calotropis procera (Ait.) R.Br., a popular medicinal species in Indian system of medicine, is widely used for the treatment of various diseases. In the present investigation the cytotoxicity of the three extracts and their fractions from aerial parts of Calotropis procera was evaluated against central nervous system (SNB-78) human cancer cell line. The results showed that hydro-alcohloic extract has more potential at three different concentrations of 10, 30 and 100 μg/ml, among all the three extracts viz., alcoholic, hydro-alcoholic and aqueous extracts. On evaluation of the various fractions, n-butanol fraction of both hydro-alcoholic and alcoholic extracts had shown antiproliferative activity against human cancer cell line of central nervous system (SNB-78) at three different concentrations of 10 and 30 μg/ml. Aqueous extract was found to be least active.

Keywords


Calotropis Procera, Aerial Parts, Extracts, Fractions, Cytotoxicity, Human Cancer Cell Line.