Effect of Thiamethoxam Alters Serum Biochemical Parameters in Channa punctatus(Bloch)

On treatment with sublethal concentration of Thiamethoxam the serum biochemical parameters of fish,Channa punctuatus could be altered. The levels of glucose, lactate, amino acid nitrogen (AAN), creatine, urea, bilirubin, phospholipids, triglycerides and non-esterified fatty acids (NEFA) increased with decrease in the level of protein, non-protein nitrogen (NPN), pyruvate and albumin during the toxic exposure periods at different time intervals in the serum of the fish.There was increase in the level of glucose due to glycogenic activity and decrease in protein level due to enhanced proteolytic activity under stress condition. Low levels of pyruvate and high level of lactic acid indicated that fish can shift from aerobic to anaerobic condition. The elevated levels of creatine, bilirubin, urea and decrease in the albumin context under stress condition revealed renal failure and acute hepatic necrosis. The levels of serum phospholipids, triglycerides, non esterified fatty acids (NEFA) were increased due to elevation which might be due to increased esterification reactions under stress condition.