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Role of Hematopoitic Stem Cells in Liver Injury
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Stem cells can be defined as cells capable of unlimited self-renewal, multilineage differentiation, and in vivo functional reconstitution of a given tissue with flexibility in the timing of this differentiation Loeffler and Roeder (2002). Until relatively recently, pluripotent stem cells were thought to derive only from embryonic sources. Embryonic stem (ES) cells derive from totipotent cells of the early postimplantation embryo and are capable of unlimited, undifferentiated proliferation in vitro while maintaining the potential to form cell types of all three germ layers Loeffler and Roeder (2002).
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