Asian Journal of Bio Science

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Effect of Novel Heterocyclic Compound on Fertility in Male Albino Rats


Affiliations
1 Reproductive Physiology Unit, Kakatiya University, Warangal (A.P.), India
2 Department of Pharmaceutical Sciences, Kakatiya University, Warangal (A.P.), India
     

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The present study has been proposed to evaluate the antifertility activity of novel hetercyclic compound in male albino rats. The ethyl 1-(5-chloro-2-oxoindolin-3-ylideneamino)-1,2,3,6-tetrahydro-4-methyl-2-oxo-6-phenyl pyrimidine -5-carboxylate compound has been found to possess significant antifertility effect in rats. Intraperitonial treatment of this compound (3mg/kg b.wt/day) for 21 days did not cause any effect on body weight. The weights of testis, cauda epididymis, seminal vesicles and ventral prostate were reduced significantly. Sperm suspension was obtained from cauda epididymis to calculate the sperm count, sperm motility sperm abnormality and fertility rate. There was a significant decrease in sperm count, sperm motility, fertility rate and a significant increase in sperm abnormality. The histological picture of testis is almost normal but the number of sperms were decreased and clumping of sperms were observed in the epididymal lumen and epithelial lining also shows degenerative changes.

Keywords

Heterocyclic Compound, Gonadosomatic Index, Fertility, Cauda Epididymis.
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  • Effect of Novel Heterocyclic Compound on Fertility in Male Albino Rats

Abstract Views: 275  |  PDF Views: 0

Authors

M. Anil Kumar
Reproductive Physiology Unit, Kakatiya University, Warangal (A.P.), India
M. Krishna Reddy
Reproductive Physiology Unit, Kakatiya University, Warangal (A.P.), India
M. Sarangapani
Department of Pharmaceutical Sciences, Kakatiya University, Warangal (A.P.), India

Abstract


The present study has been proposed to evaluate the antifertility activity of novel hetercyclic compound in male albino rats. The ethyl 1-(5-chloro-2-oxoindolin-3-ylideneamino)-1,2,3,6-tetrahydro-4-methyl-2-oxo-6-phenyl pyrimidine -5-carboxylate compound has been found to possess significant antifertility effect in rats. Intraperitonial treatment of this compound (3mg/kg b.wt/day) for 21 days did not cause any effect on body weight. The weights of testis, cauda epididymis, seminal vesicles and ventral prostate were reduced significantly. Sperm suspension was obtained from cauda epididymis to calculate the sperm count, sperm motility sperm abnormality and fertility rate. There was a significant decrease in sperm count, sperm motility, fertility rate and a significant increase in sperm abnormality. The histological picture of testis is almost normal but the number of sperms were decreased and clumping of sperms were observed in the epididymal lumen and epithelial lining also shows degenerative changes.

Keywords


Heterocyclic Compound, Gonadosomatic Index, Fertility, Cauda Epididymis.