Asian Journal of Bio Science

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Toxic Effect of Amikacin Sulphate on Liver and Kidney on White (albino) Rat


Affiliations
1 P.G. Department of Zoology, Sadguru Gadage Maharaj College, Karad, Satara, M.S., India
2 P.G. Centre of Zoology, Yashwantrao Chavan College of Science, Karad, Satara, M.S., India
3 Department of Zoology,yeshwant Mahavidyalaya, Nanded, M.S., India
4 P.G. Centre of Zoology, Krishna Mahavidyalaya, Rethare (bk.), Shivnagar, Karad, Satara, M.S., India
     

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Antibiotics are a family of medications used to treat against bacterial, fungal and parasitic infections. Numerous side effects are associated with antibiotic use and extremely high doses of antibiotics can have severe consequences. In present investigation, the approach was to study the effect of Amikacin sulphate on liver and kidney of albino rat. As this drug is reactive and the prolonged 9- days treatment to the albino rat created histopathological changes. It destroy the structure of hepatocytes, sinusoids, endothelial cells, Kuffer cells and bile canalicule in the hepatic cords. Where as in the kidney Bowman's capsule, glomerulus and their capillaries are degenerated. The cell wall of proximal convoluted tubule, loop of Henley's, distal convoluted tubule and collecting tubule are diminished. These effects are dose dependant. Due to this histopathological changes in liver and kidney will not perform their normal physiological functions. The excessive drug may destroy the liver and kidney, affect the physiology and at last leading to death of animal.

Keywords

Toxicity, Amikacin Sulphate, Albino Rat, Histopathology
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  • Battle, D.E., Sabatinis and Kurtzman, A. (1988). Nephron., 49: pp. 210-213.

  • Devenport, H.A. (1960). Histological and histochemical techniques. W.B. Saunders Company, Philadelphia, PA (U.S.A.). pp. 349.

  • Eaton, D.L. and Klassen, C.D. (1996). Principle of toxicology, (Klassen, C.D. Ed.) Toxicology- The basic science of poison, 5th Ed., pp. 417-442.

  • Gupta, P. K. and Salunkhe, D.K. (2006). Modern toxicology, Metropolitan Book Co. Pvt. Ltd. Netaji Subhash Marg, NEW DELHI (INDIA).

  • Krishnamurthy, C.R. (1985). In: Modern toxicology. Vol. I Ed. By Roullier C.H. Pub. by Academic Press, New York and London.

  • Liu, Y., Liu, J., Habeebu, S. M.,Waalkes, M. P. and Klassen, C.D. (2000). Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity. Toxicological Sciences, 57:167-176.

  • Pillai, M.M., Pawar, S.J. and Vora, S.R. (2003). Protective effects of Hydrocotyle asiatica extracts on brain during aging. Indian J. Comp. Animal Physiol., 21: 77-85.

  • Panda, S. and Kar, A. (1997). Evidence for free radical scavenging activity of ashwagandha ischolar_main powder in mice. Indian J. Physiol. Pharmacol., 41(4):424-426.

  • Rouillier, C.H. and Muller, A.F. Pub. (1995). By Academic Press New York and London.

  • Seif, E.J., Nasr, M. and EI Fattah, A.A. (). Pharmacol., 32(5):272-278.

  • Thompson, S.W. (1966). Selected histochemical and histopathological method, Pub. by: C. C. Thomas Publisher, Spring field, Illinois, USA.

  • Wachstein, M. (1963). In: The liver, Vol. I Ed. by Roullier, C.H. Pub. by Academic Press, New York and London.

  • ZBInden, G. (1969). In: The kidney, Vol. II Ed. by Roullier, C.H. Pub. by Academic Press, New York and London.


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  • Toxic Effect of Amikacin Sulphate on Liver and Kidney on White (albino) Rat

Abstract Views: 336  |  PDF Views: 0

Authors

P. L. Kadam
P.G. Department of Zoology, Sadguru Gadage Maharaj College, Karad, Satara, M.S., India
S. B. Kengar
P.G. Centre of Zoology, Yashwantrao Chavan College of Science, Karad, Satara, M.S., India
R. N. Patil
P.G. Department of Zoology, Sadguru Gadage Maharaj College, Karad, Satara, M.S., India
M. P. Chavan
P.G. Department of Zoology, Sadguru Gadage Maharaj College, Karad, Satara, M.S., India
S. S. Nanware
Department of Zoology,yeshwant Mahavidyalaya, Nanded, M.S., India
S. S. Patil
P.G. Centre of Zoology, Krishna Mahavidyalaya, Rethare (bk.), Shivnagar, Karad, Satara, M.S., India

Abstract


Antibiotics are a family of medications used to treat against bacterial, fungal and parasitic infections. Numerous side effects are associated with antibiotic use and extremely high doses of antibiotics can have severe consequences. In present investigation, the approach was to study the effect of Amikacin sulphate on liver and kidney of albino rat. As this drug is reactive and the prolonged 9- days treatment to the albino rat created histopathological changes. It destroy the structure of hepatocytes, sinusoids, endothelial cells, Kuffer cells and bile canalicule in the hepatic cords. Where as in the kidney Bowman's capsule, glomerulus and their capillaries are degenerated. The cell wall of proximal convoluted tubule, loop of Henley's, distal convoluted tubule and collecting tubule are diminished. These effects are dose dependant. Due to this histopathological changes in liver and kidney will not perform their normal physiological functions. The excessive drug may destroy the liver and kidney, affect the physiology and at last leading to death of animal.

Keywords


Toxicity, Amikacin Sulphate, Albino Rat, Histopathology

References