Asian Journal of Bio Science

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Epigenetics: New Relation of Health and Nutrition


Affiliations
1 Department of Foods and Nutrition, College of Home Science, Maharana Pratap University of Agriculture and Technology, Udaipur (Rajasthan), India
     

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The development and maintenance of an organism is orchestrated by a set of chemical reactions that switch parts of the genome off and on at strategic times and locations. Epigenetics is the study of these reactions and the factors that influence them. The nutrients we extract from food enter metabolic pathways where they are manipulated, modified and molded into molecules, the body can use. One such pathway is responsible for making methyl groups - important epigenetic tags that silence genes. Familiar nutrients like folic acid, B vitamins and SAMe (S-Adenosyl methionine) are key components of this methyl-making pathway. Diets high in these methyl-donating nutrients can rapidly alter gene expression, especially during early development when the epigenome is first being established. Nutrients can reverse or change epigenetic phenomena such as DNA methylation and histone modifications, thereby modifying the expression of critical genes associated with physiologic and pathologic processes, including embryonic development, aging, and carcinogenesis. It appears that nutrients and bioactive food components can influence epigenetic phenomena either by directly inhibiting enzymes that catalyze DNA methylation or histone modifications, or by altering the availability of substrates necessary for those enzymatic reactions. As we better understand the connections between diet and the epigenome, the opportunity arises for clinical applications. Enter the future field of nutrigenomics, where nutritionists take a look at your methylation pattern and design a personalized nutrition plan. While we're not quite to that point yet, your doctor can already tell a lot about your disease risk by looking at your family health history. In this regard, nutritional epigenetics has been viewed as an attractive tool to prevent pediatric developmental diseases and cancer as well as to delay aging-associated processes. In recent years, epigenetics has become an emerging issue in a broad range of diseases such as type 2 diabetes mellitus, obesity, inflammation and neurocognitive disorders.

Keywords

Epigenetics, Nutrients, Gene Expression, Dna Methylation, Histone Modifications, Epigenome.
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  • Berdasco, M. and Esteller, M. (2010). Aberrant epigenetic landscape in cancer: How cellular identity goes awry. Dev Cell., 19(5): 698-711.

  • Bird, A. (2007). Perceptions of epigenetics. Nature., 447 (7143): 396–398.

  • Bishop, J.B., Witt, K.L. and Sloane, R.A. (1997). Genetic toxicities of human teratogens. Mutat. Res., 396 (1–2): 9–43.

  • Burdge, G.C. and Lillycrop, K.A. (2010). Nutrition, epigenetics, and developmental plasticity: Implications for understanding human disease. Annu Rev Nutr., 30: 315-39.

  • Cicero, T.J., Adams, M.L., Giordano, A., Miller, B,T., OConnor, L. and Nock, B. (1991). Influence of morphine exposure during adolescence on the sexual maturation of male rats and the development of their offspring. J. Pharmacol. Exp. Ther., 256(3): 1086–1093.

  • Cooney, C.A., Dave, A.A. and Wolff, G.L. (2002). Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring. J. Nutr., 132 (8 Suppl): 2393S–2400S.

  • Egger, G., Liang, G., Aparicio, A. and Peter, A. (2004). Epigenetics in human disease and prospects for epigenetic therapy. Nature, 429: 457–463.

  • Gallou-Kabani, C., Vige, A., Gross, M.S. and Junien, C. (2007). Nutri-epigenomics: Lifelong remodelling of our epigenomes by nutritional and metabolic factors and beyond. Clin. Chem. Lab. Med., 45(3): 321-327.

  • Gheorghe, C.P., Goyal, R., Holweger, J.D. and Longo, L.D. (2009). Placental gene expression responses to maternal protein restriction in the mouse. Placenta., 30(5): 411-417.

  • Jablonka, E. and Raz, G. (2009). Transgenerational epigenetic inheritance: prevalence, mechanisms, and implications for the study of heredity and evolution". Q. Rev. Biol., 84 (2): 131–176.

  • Jia, G., Ye, F., Xu, Z., Qing, D., Guanqun, Z., Ying, Y., Chengqi, Y., Lindahl, T., Tao, P., Yun-Gui, Y. and Chuan, H. (2011). N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nature Chemical Biol., 7 (12) : 885–887.

  • Jones, P.A. and Baylin, S.B. (2002). The fundamental role of epigenetic events in cancer. Nature Rev. Genet., 3 : 415–428.

  • Keyes, M.K., Jang, H., Mason, J.B., Liu, Z., Crott, J.W., Smith, D.E., Friso, S. and Choi, S.W. (2007) Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon. J Nutr. 137 : 1713-1717.

  • Kirkland, J.B. (2009). Niacin status impacts chromatin structure. J. Nutr., 139 : 2397-2401.

  • Liilycrop, K.A., Phillips, E.S., Torrens, C., Hanson, M.A., Jackson, A.A. and Burdge, G.C. (2008). Feeding pregnant rats a proteinrestricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring. Br. J. Nutr., 100 (2) : 278-282.

  • Lillycrop, K.A., Slater-Jefferies, J.L., Hanson, M.A., Godfrey, K.M., Jackson, A.A. and Burdge, G.C. (2007). Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications. Br. J. Nutr., 97 (6) : 1064-1073.

  • Newbold, R.R., Padilla-Banks, E. and Jefferson, W.N. (2006) A. dverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. Endocrinol., 147 (6 Suppl) : S11–7

  • Niculescu, M.D., Craciunescu, C.N. and Zeisel, S.H. (2006).Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB J., 20 : 43-9.

  • Pembrey, M.E., Bygren, L.O., Kaati, G., Edvinsson, S., Northstone, K., Sjostrom, M., Golding, J. and ALSPAC Study Team. (2006). Sex-specific, male-line transgenerational responses in humans. Eur. J. Hum. Genet., 14 (2) : 159–66.

  • Pogribny, I.P., Ross, S.A., Tryndyak, V.P., Pogribna, M., Poirier, L.A. and Karpinets, T.V. (2006) Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. Carcinogenesis., 27 : 1180-1186.

  • Pozharny, Y., Lambertini, L., Clunie, G., Ferrara, L. and Lee, M.J. (2010). Epigenetics in women's health care. Mt. Sinai. J. Med., 77 (2) : 225-235.

  • Regine, P., Steegers-Theunissen, M., Sylvia, A., Obermann-Borst, Dennis, K., Jan, L., Cissy, S., Eric, A., Steegers, P., Eline, S., Bastiaan, T. and Heijmans (2009). Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. PLoS ONE., 4 : e7845.

  • Robertson, K.D. (2002). DNA methylation and chromatin: Unraveling the tangled web. Oncogene., 21 : 5361–5379.

  • Sinclair, K.D., Allegrucci, C., Singh, R., Gardner, D.S., Sebastian, S., Bispham, J., Thurston, A., Huntle ya,n dJ.RF.ees, W.D. (2007). DNA methylation, insulin resistance, blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc. Nat. Acad. Sci. U.S.A., 104 : 19351-19356.

  • Tamashiro, K.L. (2010). Moran TH. Perinatal environment and its influences on metabolic programming of offspring. Physiol Behav., 100 (5) : 560-566.

  • Waterland, R.A. and Jirtle, R.L. (2003). Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol. Cell. Biol., 23 (15) : 5293–5300.

  • Wood, A.J. and Oakey, R.J. (2006). Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet., 2 (11) : e147.

  • Webliography

  • Philip, H. (2008). Special report: ‘What genes remember’ Prospect Magazine May 2008 issue 146". Web.archive.org., 2008-05-01.


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  • Epigenetics: New Relation of Health and Nutrition

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Authors

Latika Yadav
Department of Foods and Nutrition, College of Home Science, Maharana Pratap University of Agriculture and Technology, Udaipur (Rajasthan), India
Pooja Maurya
Department of Foods and Nutrition, College of Home Science, Maharana Pratap University of Agriculture and Technology, Udaipur (Rajasthan), India

Abstract


The development and maintenance of an organism is orchestrated by a set of chemical reactions that switch parts of the genome off and on at strategic times and locations. Epigenetics is the study of these reactions and the factors that influence them. The nutrients we extract from food enter metabolic pathways where they are manipulated, modified and molded into molecules, the body can use. One such pathway is responsible for making methyl groups - important epigenetic tags that silence genes. Familiar nutrients like folic acid, B vitamins and SAMe (S-Adenosyl methionine) are key components of this methyl-making pathway. Diets high in these methyl-donating nutrients can rapidly alter gene expression, especially during early development when the epigenome is first being established. Nutrients can reverse or change epigenetic phenomena such as DNA methylation and histone modifications, thereby modifying the expression of critical genes associated with physiologic and pathologic processes, including embryonic development, aging, and carcinogenesis. It appears that nutrients and bioactive food components can influence epigenetic phenomena either by directly inhibiting enzymes that catalyze DNA methylation or histone modifications, or by altering the availability of substrates necessary for those enzymatic reactions. As we better understand the connections between diet and the epigenome, the opportunity arises for clinical applications. Enter the future field of nutrigenomics, where nutritionists take a look at your methylation pattern and design a personalized nutrition plan. While we're not quite to that point yet, your doctor can already tell a lot about your disease risk by looking at your family health history. In this regard, nutritional epigenetics has been viewed as an attractive tool to prevent pediatric developmental diseases and cancer as well as to delay aging-associated processes. In recent years, epigenetics has become an emerging issue in a broad range of diseases such as type 2 diabetes mellitus, obesity, inflammation and neurocognitive disorders.

Keywords


Epigenetics, Nutrients, Gene Expression, Dna Methylation, Histone Modifications, Epigenome.

References