Synthesis, Spectral Characterization and Antimicrobial Evaluation of some Heterocyclic Hydroxamic Acid Compounds

Synthesis of N-benzyl thiophene hydroxamic acid, p-chloro benzyl thiophene hydroxamic acid and p-methyl benzyl thiophene hydroxamic acid, have been carried out by coupling of thiophene -2 carbonyl chloride with benzyl hydroxyl amine, p-chloro benzyl hydroxylamine and p- methyl benzyl hydroxylamine which have been synthesized by hydrolysis of nitrone in acidic medium(con. HCl) by steam distillation which in turn have been synthesized by oxidation of di benzyl hydroxylamine, di chloro benzyl hydroxyl amine, and di methyl benzyl hydroxylamine in presence of mercuric oxide(yellow),diderivative have been obtained from reaction of hydroxylamine hydrochloride and benzyl chloride, p-chloro benzyl chloride, p- methyl benzyl chloride in ethereal medium, while N- methyl thiophene hydroxamic acid was synthesized from N- methyl hydroxyl amine obtained from reduction of nitromethane with Zn dust. Structural assignments were done on the basis of elemental analysis, IR and ¹H NMR.All the synthesized compounds were screened for their antimicrobial activity by paper-disc agar-plate method.