Synthesis and Biological Studies of Trihydro Pyrido [2, 3-D] Pyrimidines 6-Carbonitrile

Complexes of the type [ ML₂ ] and [ MLL'.H₂O ] [ where, M = Cu(II), Ni(II), Co(II), Zn(II) and Mn(II); HL = N-(2-thiazole)-2'-carboxylic acid; and L' = oxine] have been synthesized. The complexes are octahedral in nature. The synthesized ligand behaves as tridendate OON donor. The characterization of the complexes has been done on the basis of analytical, molar conductance, magnetic susceptibility, molecular weight, infrared and electronic spectral data. Antibacterial activity of these ligands and their metal complexes has been determined on gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria at 37^oC and antifungal activity has been determined on common fungi viz., Aspergillus niger, Aspergillus nidulense and Candida albicans at 28°C. It has been found that the biocidal activity of these ligands increases on being coordinated with suitable metal ion.