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Complexes of Diphenyl Amine Mercapto Carboxylic Acid:A New Anti-Inflammatory Agent
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Diphenyl amine-2-mercapto-2'-carboxylic acid and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized and characterized by their elemental analyses, molecular weight determination, molar conductance, infrared and electronic spectra and magnetic measurements. In acute anti-inflammatory test Cu(II) complex was found to be more potent than Ibuprofen in normal and adrenalectomized rats but less effective in subacute and chronic anti-inflammatory tests. It inhibited PGE2 like substance ( 25%) and Castor oil induced diarrhoea (30%) but did not protect the mice against arachidonic acid induced mortality. However, it had very low degree of gastric irritation but without analgesic effect.
Keywords
Metal Complex, NSAID’s, Prostaglandins, Anti Inflammatory Agent.
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