The Asian Journal of Experimental Chemistry

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Synthesis of N-Pyrimidino Benzamide-2-Carboxylic Acid and Evaluation of its Antimicrobial and Anti-Inflammatory Activities


Affiliations
1 Ministry of Commerce and Industry (Govt. of India), Chemical Road, Dhrangadhra (Gujarat), India
2 Department of Pharmacology, S.N. Medical College, Agra (U.P.), India
3 Thrombosis Research Unit, Sree Chitra Tirumal Institute for Medical Science and Technology, Biomedical Technological Wing, Thiruvananthapuram (Kerala), India
4 Department of Chemistry, Narayan P.G. College, Shikohabad (U.P.), India
     

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N-pyrimidino benzamide-2-carboxylic acid (NPBCA) has been synthesized. The structure of the synthesized compound has been established by using elemental analysis, molecular weight determination and infrared spectral studies. Antifungal activity of the compound has been screened on common fungi viz., Aspergillus niger, Aspergillus nidulense and Candida albicans at 28°C and antibacterial activity has been determined on gram-positive (Staphylococcus aureus) and gram-negative (Esherichia coli) bacteria at 37°C. The compound significantly inhibited 21.6 % carrageenan induced rat paw oedema at 100 mg/kg p.o. dose (LD50 > 400 mg/kg). It, however, fails to inhibit cotton pellet induced granuloma formation and oedema in adjuvant arthritis test (non established), upto a dose of 200 mg/kg p.o. It elicited ulcerogenic effect at 100 mg/kg dose.

Keywords

Benzamide Derivative, Anti-Inflammatory Activity, Ulcerogenic Acivity, Biocidal Activity.
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  • Synthesis of N-Pyrimidino Benzamide-2-Carboxylic Acid and Evaluation of its Antimicrobial and Anti-Inflammatory Activities

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Authors

Rajesh Nagar
Ministry of Commerce and Industry (Govt. of India), Chemical Road, Dhrangadhra (Gujarat), India
Govind Mohan
Department of Pharmacology, S.N. Medical College, Agra (U.P.), India
Anugya Mehta
Thrombosis Research Unit, Sree Chitra Tirumal Institute for Medical Science and Technology, Biomedical Technological Wing, Thiruvananthapuram (Kerala), India
Arvind Kumar
Department of Chemistry, Narayan P.G. College, Shikohabad (U.P.), India

Abstract


N-pyrimidino benzamide-2-carboxylic acid (NPBCA) has been synthesized. The structure of the synthesized compound has been established by using elemental analysis, molecular weight determination and infrared spectral studies. Antifungal activity of the compound has been screened on common fungi viz., Aspergillus niger, Aspergillus nidulense and Candida albicans at 28°C and antibacterial activity has been determined on gram-positive (Staphylococcus aureus) and gram-negative (Esherichia coli) bacteria at 37°C. The compound significantly inhibited 21.6 % carrageenan induced rat paw oedema at 100 mg/kg p.o. dose (LD50 > 400 mg/kg). It, however, fails to inhibit cotton pellet induced granuloma formation and oedema in adjuvant arthritis test (non established), upto a dose of 200 mg/kg p.o. It elicited ulcerogenic effect at 100 mg/kg dose.

Keywords


Benzamide Derivative, Anti-Inflammatory Activity, Ulcerogenic Acivity, Biocidal Activity.