The Asian Journal of Experimental Chemistry

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Syntheses and Anti-Inflammatory Actvity of Diphenyl-2, 2'-Dicarboxylic Acid and its Metal Complexes


Affiliations
1 Ministry of Commerce and Industry (Govt. of India), Chemical Road, Dhrangadhra (Gujarat), India
2 Department of Pharmacology, S.N. Medical College, Agra (U.P.), India
3 Thrombosis Research Unit, Sree Chitra Tirumal Institute for Medical Science and Technology, Biomedical Technological Wing, Thiruvananthapuram (Kerala), India
4 Department of Chemistry, Narayan P.G. College, Shikohabad (U.P.), India
     

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Diphenyl amine-2,2'-dicarboxylic acid and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized and characterized by their elemental analyses, molecular weight determination, molar conductance, infrared and electronic spectra and magnetic measurements. The Zinc complex was tested by different methods for anti-inflammatory activity. It was found to be equipotent to Naproxen and Ibuprofen, though in higher dosed.

Keywords

Metal Complex, NSAID’s, Prostaglandins, Anti Inflammatory Agent.
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  • Syntheses and Anti-Inflammatory Actvity of Diphenyl-2, 2'-Dicarboxylic Acid and its Metal Complexes

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Authors

Rajesh Nagar
Ministry of Commerce and Industry (Govt. of India), Chemical Road, Dhrangadhra (Gujarat), India
Govind Mohan
Department of Pharmacology, S.N. Medical College, Agra (U.P.), India
Anugya Mehta
Thrombosis Research Unit, Sree Chitra Tirumal Institute for Medical Science and Technology, Biomedical Technological Wing, Thiruvananthapuram (Kerala), India
Arvind Kumar
Department of Chemistry, Narayan P.G. College, Shikohabad (U.P.), India

Abstract


Diphenyl amine-2,2'-dicarboxylic acid and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized and characterized by their elemental analyses, molecular weight determination, molar conductance, infrared and electronic spectra and magnetic measurements. The Zinc complex was tested by different methods for anti-inflammatory activity. It was found to be equipotent to Naproxen and Ibuprofen, though in higher dosed.

Keywords


Metal Complex, NSAID’s, Prostaglandins, Anti Inflammatory Agent.