The Asian Journal of Experimental Chemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Syntheses and Anti-Inflammatory Actvity of Diphenyl-2, 2'-Dicarboxylic Acid and its Metal Complexes


Affiliations
1 Ministry of Commerce and Industry (Govt. of India), Chemical Road, Dhrangadhra (Gujarat), India
2 Department of Pharmacology, S.N. Medical College, Agra (U.P.), India
3 Thrombosis Research Unit, Sree Chitra Tirumal Institute for Medical Science and Technology, Biomedical Technological Wing, Thiruvananthapuram (Kerala), India
4 Department of Chemistry, Narayan P.G. College, Shikohabad (U.P.), India
     

   Subscribe/Renew Journal


Diphenyl amine-2,2'-dicarboxylic acid and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized and characterized by their elemental analyses, molecular weight determination, molar conductance, infrared and electronic spectra and magnetic measurements. The Zinc complex was tested by different methods for anti-inflammatory activity. It was found to be equipotent to Naproxen and Ibuprofen, though in higher dosed.

Keywords

Metal Complex, NSAID’s, Prostaglandins, Anti Inflammatory Agent.
Subscription Login to verify subscription
User
Notifications
Font Size

Abstract Views: 216

PDF Views: 1




  • Syntheses and Anti-Inflammatory Actvity of Diphenyl-2, 2'-Dicarboxylic Acid and its Metal Complexes

Abstract Views: 216  |  PDF Views: 1

Authors

Rajesh Nagar
Ministry of Commerce and Industry (Govt. of India), Chemical Road, Dhrangadhra (Gujarat), India
Govind Mohan
Department of Pharmacology, S.N. Medical College, Agra (U.P.), India
Anugya Mehta
Thrombosis Research Unit, Sree Chitra Tirumal Institute for Medical Science and Technology, Biomedical Technological Wing, Thiruvananthapuram (Kerala), India
Arvind Kumar
Department of Chemistry, Narayan P.G. College, Shikohabad (U.P.), India

Abstract


Diphenyl amine-2,2'-dicarboxylic acid and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized and characterized by their elemental analyses, molecular weight determination, molar conductance, infrared and electronic spectra and magnetic measurements. The Zinc complex was tested by different methods for anti-inflammatory activity. It was found to be equipotent to Naproxen and Ibuprofen, though in higher dosed.

Keywords


Metal Complex, NSAID’s, Prostaglandins, Anti Inflammatory Agent.