Asian Journal of Pharmaceutical Analysis

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UV-Spectroscopic Estimation and Validation of Drotaverine Concentration in Bulk and Dosage Form


Affiliations
1 Department of Quality Assurance, Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, India
     

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A simple, accurate, precise, and sensitive a highly selective ultra violet spectrophotometric method has been developed for the validation and estimation in bulk and dosage form. It shows maximum absorbance 286 nm. Beer-Lambert's was obeyed in the concentration range of in the range of 15-55μg/ml. The method was successfully validated in accordance to ICH guideline for accuracy, precision, linearity and robustness. The linear regression analysis data for calibration plots showed good linear relationship and obtain correlation factor 0.9927 for Drotaverine. Thus method was successfully applied for routine analysis of Drotaverine in bulk samples.

Keywords

Drotaverine, ICH, UV- Spectroscopy, Accuracy, Precision.
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  • UV-Spectroscopic Estimation and Validation of Drotaverine Concentration in Bulk and Dosage Form

Abstract Views: 253  |  PDF Views: 1

Authors

Vedantika Das
Department of Quality Assurance, Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, India
Ashwini Sambherao
Department of Quality Assurance, Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, India
Saroj Gajare
Department of Quality Assurance, Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, India
Amar Zalte
Department of Quality Assurance, Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, India
R. B. Saudagar
Department of Quality Assurance, Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, India

Abstract


A simple, accurate, precise, and sensitive a highly selective ultra violet spectrophotometric method has been developed for the validation and estimation in bulk and dosage form. It shows maximum absorbance 286 nm. Beer-Lambert's was obeyed in the concentration range of in the range of 15-55μg/ml. The method was successfully validated in accordance to ICH guideline for accuracy, precision, linearity and robustness. The linear regression analysis data for calibration plots showed good linear relationship and obtain correlation factor 0.9927 for Drotaverine. Thus method was successfully applied for routine analysis of Drotaverine in bulk samples.

Keywords


Drotaverine, ICH, UV- Spectroscopy, Accuracy, Precision.