Asian Journal of Pharmaceutical Analysis

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Simultaneous Estimation of Drotaverine HCl and Nimesulide in a Tablet Formulation by Absorbance Ratio Method


Affiliations
1 Department of Pharmaceutical Chemistry, MVP College of Pharmacy, University of Pune, Maharashtra, Nashik 422002, India
2 Department of Pharmaceutical Chemistry, M.G.V’s Pharmacy College (Pune University), Mumbai, India
3 KCT’s R. G. Sapkal College of Pharmacy, Anjineri, Nashik, Maharashtra, India
     

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Spectrophotometric method were proposed for the simultaneous analysis of Drotaverine HCl and Nimesulide in a tablet formulationby absorbance ratio method at 278 nm (isoabsorptive point) and 304 nm(λ max of Drotaverine HCl ) with mean percentage recovery 98.25%±0.66 and 100.5%±0.95, respectively. Beer's law for both methods was obeyed in the concentration range 5-25μg/ml of drotaverine HCl and Nimesulide respectively. The suggested method were successfully applied for the analysis of the two drugs in their pharmaceutical formulation. The obtained results were statistically agreed with those obtained by the reported method.

Keywords

Drotaverine HCl, Nimesulide, Absorbance Ratio Method.
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  • Simultaneous Estimation of Drotaverine HCl and Nimesulide in a Tablet Formulation by Absorbance Ratio Method

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Authors

Ashok P. Pingale
Department of Pharmaceutical Chemistry, MVP College of Pharmacy, University of Pune, Maharashtra, Nashik 422002, India
A. R. Rote
Department of Pharmaceutical Chemistry, M.G.V’s Pharmacy College (Pune University), Mumbai, India
R. B. Saudagar
KCT’s R. G. Sapkal College of Pharmacy, Anjineri, Nashik, Maharashtra, India
Rima R. Patil
Department of Pharmaceutical Chemistry, M.G.V’s Pharmacy College (Pune University), Mumbai, India
G. B. Jadhav
KCT’s R. G. Sapkal College of Pharmacy, Anjineri, Nashik, Maharashtra, India

Abstract


Spectrophotometric method were proposed for the simultaneous analysis of Drotaverine HCl and Nimesulide in a tablet formulationby absorbance ratio method at 278 nm (isoabsorptive point) and 304 nm(λ max of Drotaverine HCl ) with mean percentage recovery 98.25%±0.66 and 100.5%±0.95, respectively. Beer's law for both methods was obeyed in the concentration range 5-25μg/ml of drotaverine HCl and Nimesulide respectively. The suggested method were successfully applied for the analysis of the two drugs in their pharmaceutical formulation. The obtained results were statistically agreed with those obtained by the reported method.

Keywords


Drotaverine HCl, Nimesulide, Absorbance Ratio Method.