Spectrophotometric Method of Choline Bitartrate in Bulk and its Tablet Formulation

A Simple, precise, rapid and accurate UV spectrophotometric method was developed for the estimation of Choline Bitartrate in bulk and its tablet formulation. UV scan of Choline Bitartrate showed max (absorbance) value at 208 nm in the concentration range of 10 μg/ml. This method is based on the measurement of light absorption in the UV region using water as solvent. Beer's Law plot was constructed by measuring the absorbance at 208 nm using various concentration of solution 5-35 μg/ml and show linearity and limit of detection. A simple and convenient method is applied to the determination of amount of choline bitartrate present in tablet formulation with high percentage of recovery, good accuracy and precision. The results are found satisfactory and reproducible. The proposed method was successfully extended to pharmaceutical preparation tablet.