Dual Wavelength Spectrophotometric Method for the Simultaneous Determination of Paracetamol and Nabumetone in API and in Tablet Dosage Form

A simple, sensitive and rapid dual wavelength spectrophotometric method has been developed for simultaneous determination of Nabumetone and Paracetamol from tablets. Two wavelength method was used to eliminate interference due to absorbance of other drug at sampling wavelengths for one drug. Nabumetone was estimated directly from absorbance at its sampling wavelength (332.6 nm) at which Paracetamol showed no absorbance. Paracetamol was estimated at 237.4 nm and 214.4 nm where interference due to absorbance of Nabumetone was eliminated. Linearity of response was observed in concentration range of 2 - 20 μg/ml for Nabumetone and 4 - 20 μg/ml for Paracetamol. Lower limit of detection (LOD) for NABU and PCM were found to be 0.30 μg/ml and 0.41 μg/ml respectively. Lower limit of quantification (LOQ) for NABU and PCM were found to be 0.92 μg/ml and 1.24 μg/ml respectively. The % recovery was found to be 98.62% to 101.80% for Nabumetone whereas 98.50% to 100.49% for Paracetamol. The results of analysis in terms of % label claim was 99.51% ± 0.13 for Nabumetone and 98.83% ± 0.06 for Paracetamol for a formulation analyzed. The developed method was found to be accurate, precise, selective and rapid for simultaneous estimation of Nabumetone and Paracetamol in tablet dosage form.