Spectrophotometric Estimation of Lisinopril and Cefixime in Bulk and Dosage Forms

Simple and accurate spectrophotometric methods for determination of Lisinopril and Cefixime in bulk and dosage forms are described. The First method is used for determination of Lisinopril through ternary complex formation between Lisinopril, Congo Red and either Nickel or Copper in presence of borate buffer PH 7.5, colour produced has peak maxima at 499 and 497, respectively. Beer's law is obeyed in range of 20-80 μg and 10-50 μg, respectively. Second method is used for estimation of Cefixime through formation of ion pair complex with Congo Red in presence of borate buffer PH 7.5, produced complex has a peak maximum at 595 nm. Beer's law is obeyed in range of 20-65 μg. Limit of detection and quantitation and Sandel sensitivity has been calculated. Proposed methods were applied for determination of both drugs in some of their pharmaceutical preparations. The Proposed methods were validated and obtained results were compared statistically with reference methods.