Asian Journal of Pharmaceutical Analysis

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Development and Validation of Visible Method for Estimation of Cilazapril in Bulk Formulation by MBTH Reagent


Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India
     

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A simple, sensitive, accurate, precise and economical visible Spectrophotometric method was developed and validated for the estimation of Cilazapril in Bulk form. The method is based on the reaction of Cilazapril with MBTH Reagent [3-Methyl-2-Benzothiazolinone Hydrazone] in the presence of Ferric chloride producing greenish yellow colour chromogen which shows maximum absorbance at 402nm against reagent blank. The Chromogen obeyed Beer's law in the concentration range of 10-50 μg/ml for Cilazapril. The results of the analysis have been validated statistically and recovery studies.

Keywords

Cilazapril, MBTH Reagent, Ferric Chloride, Visible Spectrophotometric.
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  • Development and Validation of Visible Method for Estimation of Cilazapril in Bulk Formulation by MBTH Reagent

Abstract Views: 295  |  PDF Views: 1

Authors

Chavi Dagar
Department of Pharmaceutical Analysis and Quality Assurance, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India
G. Rohit Reddy
Department of Pharmaceutical Analysis and Quality Assurance, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India
V. V. S. Rajendra Prasad
Department of Pharmaceutical Analysis and Quality Assurance, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India

Abstract


A simple, sensitive, accurate, precise and economical visible Spectrophotometric method was developed and validated for the estimation of Cilazapril in Bulk form. The method is based on the reaction of Cilazapril with MBTH Reagent [3-Methyl-2-Benzothiazolinone Hydrazone] in the presence of Ferric chloride producing greenish yellow colour chromogen which shows maximum absorbance at 402nm against reagent blank. The Chromogen obeyed Beer's law in the concentration range of 10-50 μg/ml for Cilazapril. The results of the analysis have been validated statistically and recovery studies.

Keywords


Cilazapril, MBTH Reagent, Ferric Chloride, Visible Spectrophotometric.