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Novel Colorimetric Methods for Quantitative Estimation of Diacerin from Capsule Formulation
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Two simple and sensitive colorimetric methods have been developed for the quantitative estimation of Diacerin from Pharmaceutical Capsule dosage form. Developed methods are based on the formation of chloroform extractable ion pair coloured complex of drug with Orange II (Method A) and Tropoelin (Method B). The complex formed in method A and B showed maximum absorbance at 435. Linearity was obeyed in concentration range of 50-350 μgm/ml and 50-250 μgm/ml of Diacerin for method A and B respectively. The results of analysis were validated statistically and by recovery studies.
Keywords
Diacerin, Orange II, Tropoelin, Colorimetric Method
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- Han-Chun Yao, Xiao-Feng Yang, Sensitive Determination of Nanogram Levels of Diacerein in a Pharmaceutical Formulation by Flow Injection Chemiluminescence Analysis, Journal of the Chinese Chemical Society, 2007, 54, 949-956
- http://en.wikipedia.org/wiki/Diacerin
- G.Abirami, K.Anandakumar, R.Velmurugan, Development And Validation of UV-Spectroscopy Method For The Determination of Diacerin Hydrochloride in Pharmaceutical Formulation, Journal of Pharmacy Research,2012;5(4),1949-1951.
- D M Dhaduk, B G Rathod, P B Patel, Estimation of Sildenafil Citrate and Diacerin Hydrochloride in their Combined Dosage Form by Validated UV Spectroscopic method, Inventi Rapid: Pharm Analysis & Quality Assurance , Vol. 2012 , Article ID- " Inventi:ppaqa/337/12 "
- P.Selvam, U.Mahalingam, D.Sridharan, and A.Thenmozhi. A Simple UV Spectrophotometric Determination of Diacerein In Pure and In Pharmaceutical Dosage Form, Asian Journal of Biochemical and Pharmaceutical Research, Vol. 1,( 3) 2011
- Sandeepa Bhoir, Shashikant Dhole, Nilesh Kulkarni, Prajakta Sangole, Sonal Thorat, Dhanashree Bhoite, Novel and validated spectrophotometric estimation of diacerein in bulk and capsule formulation using mixed hydrotropic solubilisation approach, International Journal of Pharmacy and Pharmaceutical Sciences, Vol 4, Suppl 4, 2012
- Sohan S. Chitlange, Ganesh R. Pawbake, Amir I. Mulla, Sagar B. Wankhede, Simultaneous Spectrophotometric Estimation of Diacerein and Aceclofenac in tablet dosage form, Der Pharma Chemica, 2010, 2(1): 335-341.
- Krishna R Gupta, Varun E Samrit, Vivek S Thakur and A. T. Hemke, UV-Spectrophotometric estimation of Diacerein in pharmaceutical formulation, Journal of Chemical and Pharmaceutical Research, 2010, 2(3):467-472
- Narendra Kumar Nyola and Naresh Kalra, Spectrophotometric determination of Diacerin in bulk and pharmaceutical formulation, International Journal of Pharma and Bio Sciences, Oct-Dec.2010,Vol.1(4)
- Ravindra Pandey,P.O.Patil,M.U.Patil,P.K.Deshmukh,S.B.Bari, Quantitative estimation of Diacerein in bulk and capsule formulation using mixed hydrotropic solubilisation by UV spectroscopy and first order derivative method using area under curve method,Pharmaceutical Methods,Jan-June 2012,Vol 3 (1),4-8
- K.R .Sreejith,.K.Premalatha, Novel Spectrophotometric Methods for Estimation of Diacerein from Formulations, International Journal of Research in Pharmaceutical and Biomedical Sciences, Vol. 2 (3) Jul – Sep 2011,992-999
- R Sivakumar, PK Nallasivan, KC Saranya, WD Sam Solomon, T Akelesh, R Venkatnarayanan Visible spectrophotometric estimation of diacerein in bulk and pharmaceutical dosage forms, Pharm Analysis, Year : 2010 ,Volume : 2 ,(4) Page : 414-41
- R Sivakumar, PK Nallasivan, KC Saranya, Solomon WD Sam, T Akelesh, and R Venkatnarayanan, Visible Spectrophotometric Estimation of Diacerein in Bulk and Pharmaceutical Dosage Forms, J Young Pharm. 2010 Oct-Dec; 2(4): 414–416
- Hamilton CL, Cornpropst JD., Determination of Diacerin, an investigational agent with the potential for treating depression, and its mono- and di-desmethyl metabolites in human plasma using column-switching high-performance liquid chromatography, J Chromatogr.,1993;612(2):253-61.
- Abha D. Giri, Vidhya K. Bhusari, Sunil R Dhaneshwar, Validated HPLC Method for Simultaneous Quantitation of Tadalafil and Diacerin Hydrochloride in Bulk Drug and Formulation,, International Journal of Pharmacy and Pharmaceutical Sciences,2012;4(2):654-658.
- S. P. Gandhi, M. G. Dewani, T. C. Borole and M. C. Damle, Development and validation of stability Indicating HPLC method for determination of Diacerein and aceclofenac as bulk drug and In tablet dosage form, International journal of research in pharmacy and chemistry, 2011, 1(4)
- Keddal G. Lalithaa, Thangavel Venkatachalamb, Ramaraj Srinivasanb, Ponnusamy Kalaiselvib, Nagappan Kannappan, A Simple HPLC Method for Quantitation of Diacerein in Tablet Dosage Form, Eurasian J. Anal. Chem. 5(1): 81-88, 2010
- Krishna R Gupta, Varun E. Samrit, Anuradha H Mahapatra, Sudhir G.Wadodkar, Stability indicating HPLC assay method for Diacerein and Aceclofenac in tablets, 2011Volume 1, (3)
- Rao J, Chauhan K, Mahadik KR, Kadam SS. A stabilityindicating high performance liquid chromatographic method for the determination of diacerein in capsules. Indian J Pharm Sci 2009;71:24-9
- S. P. Gandhi, M. G. Dewani, T. C. Borole and M. C. Damle, Development and validation of stability indicating HPLC method for determination of Diacerein AND Aceclofenac as bulk drug and in tablet dosage form, international journal of research in pharmacy and chemistry, 2011, 1(4),779-806
- Keddal G. Lalithaa, Thangavel Venkatachalamb, Ramaraj Srinivasanb, Ponnusamy Kalaiselvib, Nagappan Kannappanc, A Simple HPLC Method for Quantitation of Diacerein in Tablet Dosage Form, Eurasian J. Anal. Chem. 5(1): 81-88, 2010
- KS Rao, NK Keshar, J Datta, Stability indicating RP-HPLC method for the simultaneous estimation of Diacerein and Aceclofenac in bulk and pharmaceutical dosage forms Inventi Impact: Pharm Analysis & Quality Assurance , Vol. 2010
- D. Kiran Kumar, K.S. Nataraj, K. Kesinath Reddy, S. Suresh Kumar, Method Development and Validation for analysis of Diacerin in Bulk and Pharmaceutical Dosage Form by RP-HPLC.
- N. Kannappan, Madhukar A., R. Srinivasan, R.L.A. Srinivas , C H. Naveen Kumar, Mannavalan. R, Analytical method development and validation of Diacerein Tablets by RP-HPLC, Vol.2, No.1, , Jan-Mar 2010, 143-148.
- Narendra Nyola, Govinda Samy Jeyabalan, N Kalra, Gazala Parveen, and Suresh Choudhary, Development and Validation of a RP-HPLC Method for Simultaneous Estimation of Diacerein and Aceclofenac in Pharmaceutical Dosage Form, Research and Reviews: Journal of Pharmaceutical Analysis, Oct–Dec, 2012,Vol 1 ( 1 )
- Arun Shirwaikar, A. Sarala Devi, K Premalatha and KR. Sreejith, Determination of Diacerein in Rabbit Plasma by Liquid Chromatography - Mass Spectroscopy and Its Application to Bioavailability Study, International Journal of Research in Pharmaceutical and Biomedical Sciences, Oct – Dec 2012,Vol. 3 (4),1738-1744
- S. P. Gandhi, M. G. Dewani, T. C. Borole, and M. C. Damle,Development and Validation of Stability Indicating HPTLC Method for Determination of Diacerein and Aceclofenac as Bulk Drug and in Tablet Dosage Form, E-Journal of Chemistry, 2012, 9(4), 2023-2028
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