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Docking of Hematoporphyrin on Various Anticancer Drugs Targeting Enzymes


Affiliations
1 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai, India
2 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai, India
     

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The present study deals with docking of Hematoporphrin with various anticancer drugs targeting enzymes. The targets used were PDB-ID 2Y3I, PDB-ID 3OZZ, PDB-ID 3UEN and PDB-ID 4O33. Hematoporphyrin docked with these enzymes and interactions between the enzyme and compound were measured and compared with standard Paclitaxel. The study concluded that, the compound (Hematoporphyrin) isolated from plant were high interactions with PDB-ID 4O33 when compared to standard.

Keywords

Docking, Hematoporphyrin, Paclitaxel, Protein Data Bank, Interactions.
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  • Docking of Hematoporphyrin on Various Anticancer Drugs Targeting Enzymes

Abstract Views: 329  |  PDF Views: 0

Authors

S. Nandhini
Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai, India
R. Radha
Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai, India
R. Vadivu
Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai, India

Abstract


The present study deals with docking of Hematoporphrin with various anticancer drugs targeting enzymes. The targets used were PDB-ID 2Y3I, PDB-ID 3OZZ, PDB-ID 3UEN and PDB-ID 4O33. Hematoporphyrin docked with these enzymes and interactions between the enzyme and compound were measured and compared with standard Paclitaxel. The study concluded that, the compound (Hematoporphyrin) isolated from plant were high interactions with PDB-ID 4O33 when compared to standard.

Keywords


Docking, Hematoporphyrin, Paclitaxel, Protein Data Bank, Interactions.