Biologically Active Pyrimidine Hydrazones

Pyrimidine constitutes an important class of heterocycles in drug discovery and is very well known for their anticancer, antimicrobial, antioxidant and antiviral activities. Hydrazones is a class of organic compounds with the structure R1R2C=NNH2. They are formed usually by the action of hydrazine on ketones or aldehydes and have efficient CNS depressant, analgesics activity. In the same context, Schiff bases of pyrimidine hydrazones can be prepared by the reaction of "4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid hydrazide" with various terpenes such as citral, camphor, furfuraldehyde and menthone to make Schiff bases individually by refluxing them in the presence of glacial acetic acid (as solvent) for at least 2hrs to yield their respective derivatives.

The present studies revealed that Pyrimidine hydrazone derivatives could be used to synthesize the compounds having potent biological activities such as anticancer, antimicrobial, antioxidant, CNS depressant, analgesic and antiviral activities. All the prepared derivatives were under investigation for their antimicrobial activity and likely to possess the same and desired action.