Gastro-Retentive Mucoadhesive Nanoparticle for Sustained Drug Delivery System

In recent year's scientific and technological advancement have been made in the rate sustained oral drug delivery system by o overcoming physiological adversities, such as short gastric residence time (GRT) and unpredictable gastric emptying time (GET). So an interest increased towards novel dosage forms, that can retained in the stomach for a prolonged and predictable period of time. The concept of such novel dosage forms is to decrease the GI transit rate of the drug delivery system by attachment to the mucus layer, thereby increasing the overall time for drug absorption. This review presents a broad treatment of mucoadhesive nanoparticles discussing their advantages, limitations and their possible remedies.This review presents the most outstanding contributions in the field of gastro retentive mucoadhesive nanoparticles used as drug delivery systems. Methods of preparation, drug loading and drug release are covered. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a sustained rate of drug release for improved therapeutic outcome. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first-pass metabolism. This review article aims to provide an overview of the various aspects of mucoadhesion, mucoadhesive approaches, factors affecting mucoadhesion, evaluating methods, and finally various mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal).