Emerging Trends in Floating Drug Delivery Systems

Conventional drug delivery system gives as well as maintain the steady state drug concentration in blood by increasing the dosing frequency so many times. A rational approach to enhance bioavailability and improve pharmacokinetic and pharmacodynamic profiles is to retain the drug reservoir above its absorption area, to release the drug in a controlled manner. One of the most feasible approaches for achieving a prolonged and predictable drug delivery profile is to control the gastric residence time in GIT. Several approaches are currently utilized in the prolongation of the gastric residence times, including floating drug delivery systems, swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems and other delayed gastric emptying devices. This review explains briefly about Gastroretentive approaches, evaluation various floating drug delivery systems and application of these systems.