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Emulgel:Review on Novel Approach to Topical Drug Delivery


Affiliations
1 Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupathi-517102, Chittoor District, Andhra Pradesh, India
2 Department of Pharmaceutical Analysis, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupathi-517102, Chittoor District, Andhra Pradesh, India
3 Department of Pharmaceutical Chemistry, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupathi-517102, Chittoor District, Andhra Pradesh, India
4 Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupathi-517102, Chittoor District, Andhra Pradesh, India
     

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A gel is colloid that is typically 99% by weight liquid. Gels are defined as a substantially dilute cross-linked system, which exhibits no flow when in the steady-state. A major limitation is in the delivery of hydrophobic drugs. To overcome the limitation a novel approach i.e. an emulsion based approach is being used so that even a hydrophobic moiety can enjoy the unique properties of gels. When gel and emulsion are used in combined form the dosage form are referred as emulgel. Emulgels have emerged as one of the most interesting topical delivery system as it has dual release control system i.e. gel and emulsion. The presence of a gelling agent in the water phase converts a classical emulsion into an emulgel. Emulgels for dermatological use have several favorable properties such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, non staining, water-soluble, longer shelf life, bio-friendly, transparent and pleasing appearance. The use of emulgel can be extended in analgesics and antifungal drugs.

Keywords

Emulgel, Hydrophobic, Topical Drug Delivery.
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  • Emulgel:Review on Novel Approach to Topical Drug Delivery

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Authors

S. Eswaraiah
Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupathi-517102, Chittoor District, Andhra Pradesh, India
K. Swetha
Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupathi-517102, Chittoor District, Andhra Pradesh, India
M. Lohita
Department of Pharmaceutical Analysis, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupathi-517102, Chittoor District, Andhra Pradesh, India
P. Jaya Preethi
Department of Pharmaceutical Chemistry, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupathi-517102, Chittoor District, Andhra Pradesh, India
B. Priyanka
Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupathi-517102, Chittoor District, Andhra Pradesh, India
Kiran Kumar Reddy
Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupathi-517102, Chittoor District, Andhra Pradesh, India

Abstract


A gel is colloid that is typically 99% by weight liquid. Gels are defined as a substantially dilute cross-linked system, which exhibits no flow when in the steady-state. A major limitation is in the delivery of hydrophobic drugs. To overcome the limitation a novel approach i.e. an emulsion based approach is being used so that even a hydrophobic moiety can enjoy the unique properties of gels. When gel and emulsion are used in combined form the dosage form are referred as emulgel. Emulgels have emerged as one of the most interesting topical delivery system as it has dual release control system i.e. gel and emulsion. The presence of a gelling agent in the water phase converts a classical emulsion into an emulgel. Emulgels for dermatological use have several favorable properties such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, non staining, water-soluble, longer shelf life, bio-friendly, transparent and pleasing appearance. The use of emulgel can be extended in analgesics and antifungal drugs.

Keywords


Emulgel, Hydrophobic, Topical Drug Delivery.