Asian Journal of Pharmaceutical Research

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Design, Synthesis and Anti Microbial, Anti-Inflammatory, Antitubercular Activities of Some 2,4,5-Trisubstituted Imidazole Derivatives


Affiliations
1 Department of Pharmaceutical Sciences, Bhagwant University, Ajmer, Rajashthan, India
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S., India
     

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A Novel Series of Some 2,4,5-trisubstituted imidazole derivatives were prepared with the aim to get better antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activity. The structures of synthesized compounds were supported by means of IR, 1H NMR. Title compounds were evaluated for antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activities. Among the synthesized compounds some compounds found to possess all these activities. The QSAR study for anti-inflammatory activity shows good results.

Keywords

QSAR, Antibacterial, Antifungal, Anti-Inflammatory Activity.
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  • Design, Synthesis and Anti Microbial, Anti-Inflammatory, Antitubercular Activities of Some 2,4,5-Trisubstituted Imidazole Derivatives

Abstract Views: 285  |  PDF Views: 1

Authors

R. S. Kalkotwar
Department of Pharmaceutical Sciences, Bhagwant University, Ajmer, Rajashthan, India
R. B. Saudagar
Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S., India

Abstract


A Novel Series of Some 2,4,5-trisubstituted imidazole derivatives were prepared with the aim to get better antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activity. The structures of synthesized compounds were supported by means of IR, 1H NMR. Title compounds were evaluated for antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activities. Among the synthesized compounds some compounds found to possess all these activities. The QSAR study for anti-inflammatory activity shows good results.

Keywords


QSAR, Antibacterial, Antifungal, Anti-Inflammatory Activity.