Matrix Tablet:A Promising Tool for Oral Controlled Release Drug Delivery

Oral drug delivery is the leading and the oldest segment of the total drug delivery system in the market. It is the greatest growing and most favored route for drug administration so oral controlled release of drugs becomes a very promising approach for drugs that having the shorter half-life and high dose frequency. Matrix tablets are an interesting option and new breakthrough when developing an oral controlled release drugs delivery system. The present study providing the recent literature focus on controlled release drug delivery system, oral controlled release drugs delivery system, formulation of matrix tablets, mechanist models for drug release, mechanism of drug release from matrix tablet and parameters affecting the drug release. The use of various classes of release rate retardants like hydrophilic, hydrophobic, biodegradable polymers and their degradation products are focused also. Release of drugs from matrices formulated with hydrophobic polymers is slower than from matrices formulated with hydrophilic polymers. Hydroxypropyl methyl cellulose is the one most widely used as a drug release retardant excipients which is hydrophilic, non-ionic, gels when in contact with water and stable at a pH between 3.0 and 11.0 and resists enzyme attack.