Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Antiulcer Activity of Euphorbia hirta against Experimentally Induced Ulcer in Rats


Affiliations
1 Department of Ophthalmology, Sri Lakshminarayana Institute of Medical Sciences, Pondicherry, India
2 Department of Pharmacology, Sri Lakshminarayana Institute of Medical Sciences, Pondicherry, India
3 Department of Pharmacology, Nandha College of Pharmacy and Research Institute, Erode-638052, India
     

   Subscribe/Renew Journal


Euphorbia hirta, an important medicinal herb, belongs to genus Euphorbia, family Euphorbiaceae, which has been presumed for its favorable medicinal effects. The present study was undertaken to evaluate the ethanolic extract of Euphorbia hirta aerial parts for its anti-ulcer activity by various gastric ulcer models. Oral administration of the Euphorbia hirta at 200 and 400 mg/kg significantly inhibited ulcer formation induced by various ulcer models like pylorus ligation, indomethacin, HCl/EtOH and restraint-stress in rats. In pylorus-ligated rats, pretreatment with the Euphorbia hirta extract had reduced gastric secretion. In HCl/EtOH induced ulcerated rats, gastric wall mucus was significantly preserved by the Euphorbia hirta pretreatment at doses of 200 and 400 mg/kg. The findings indicate that the ethanolic extract of Euphorbia hirta possesses gastroprotective potential which is related partly to preservation of gastric mucus secretion and anti secretary action.

Keywords

Euphorbia hirta, Pylorus Ligation, Antiulcer and Gastroprotective.
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 258

PDF Views: 1




  • Antiulcer Activity of Euphorbia hirta against Experimentally Induced Ulcer in Rats

Abstract Views: 258  |  PDF Views: 1

Authors

K. Rathnakumar
Department of Ophthalmology, Sri Lakshminarayana Institute of Medical Sciences, Pondicherry, India
S. Jaikumar
Department of Pharmacology, Sri Lakshminarayana Institute of Medical Sciences, Pondicherry, India
S. Sengottuvelu
Department of Pharmacology, Nandha College of Pharmacy and Research Institute, Erode-638052, India

Abstract


Euphorbia hirta, an important medicinal herb, belongs to genus Euphorbia, family Euphorbiaceae, which has been presumed for its favorable medicinal effects. The present study was undertaken to evaluate the ethanolic extract of Euphorbia hirta aerial parts for its anti-ulcer activity by various gastric ulcer models. Oral administration of the Euphorbia hirta at 200 and 400 mg/kg significantly inhibited ulcer formation induced by various ulcer models like pylorus ligation, indomethacin, HCl/EtOH and restraint-stress in rats. In pylorus-ligated rats, pretreatment with the Euphorbia hirta extract had reduced gastric secretion. In HCl/EtOH induced ulcerated rats, gastric wall mucus was significantly preserved by the Euphorbia hirta pretreatment at doses of 200 and 400 mg/kg. The findings indicate that the ethanolic extract of Euphorbia hirta possesses gastroprotective potential which is related partly to preservation of gastric mucus secretion and anti secretary action.

Keywords


Euphorbia hirta, Pylorus Ligation, Antiulcer and Gastroprotective.