Design, Formulation and In Vitro Drug Release from Transdermal Patches Containing Nebivolol Hydrochloride as Model Drug

The aim of the present investigation was to form matrix type transdermal patches containing Nebivolol hydrochloride were prepared using two polymers by solvent evaporation technique to minimize the dose of the drug for lesser side effect and increase bioavailability of drug. Aluminium foil was used as a backing membrane. Polyethylene glycol (PEG) 400 was used as plasticizer and Dimethyl sulfoxide (DMSO) was used as penetration enhancer. Drug polymer interactions determine by FTIR and standard calibration curve of ketoprofen were determine by using UV estimation. The formulated transdermal patch by using EudragitRS100, HPMC K100M, showed good physical properties. All prepared formulations indicated good physical stability. In-vitro drug permeation studies of formulations were performed by using Franz diffusion cells using abdomen skin of Wistar albino rat. Result, showed best in-vitro skin permeation through rat skin (Wistar albino rat) as compared to all other formulations prepared with hydrophilic polymer containing permeation enhancer. It was observed that the formulation containing HPMC: EudragitRS100 (8:2) showed ideal higuchi release kinetics. On the basis of in vitro drug release through skin permeation performance, Formulation F1 was found to be better than other formulations and it was selected as the optimized formulation.