Skin Cancer:Dance of Death

Protection against sun-induced damage leading to photo carcinogenesis in skin is a highly desirable goal. Epidemiological and experimental studies provide evidence that some naturally occurring chemical agents in the human diet can diminish cancer risk. Extensive documentation has validated the role of UV irradiation as a tumor initiator and promoter, inducing both squamous and basal cell carcinomas. Development of skin cancer has been frequently observed in patients with XP. This disease is characterized by deleterious mutations in the genes involved in the DNA damage repair system, with a marked reduction in the ability of its cells to repair potentially carcinogenic mutations mainly those caused by UV, thus making these patients highly photosensitive and predisposed to skin cancer. The article highlights important factors, types of skin cancer with its mechanisms and prevention strategy.