Asian Journal of Pharmaceutical Research

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In Vitro Antioxidant Evaluation of Mimosa pudica


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1 Meenakshi Chandrasekaran Arts and Science College, Dept. of Life Sciences, Pattukkottai-614626, Thanjavur, Tamilnadu, India
     

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The study of free radicals and antioxidants in biology is producing medical revolution that promises a new age of health and disease management. The present study was performed to evaluate the in vitro antioxidant effect of the ethanolic extract of Mimosa pudica (Mimosaceae) against free radical damage by different standard methods such as DPPH (1,1-diphenyl-2-picrylhydrazyl), Nitric Oxide (NO), ABTS (2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid)) and Hydrogen peroxide free radical model. The test extract exhibited significant inhibition in Nitric oxide and DPPH free radical formation with IC50 values of 78.1±1.75 and 35.00±1.15 μg/ml respectively. Whereas in the cases of ABTS and Hydrogen peroxide free radicals IC50 values of 81.00±3.85 and 449.60±2.55 μg/ml. Out of these four free radicals the extract showed potent activity on Nitric oxide and DPPH, which is compared to that of ascorbic acid and rutin taken as standards.
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  • In Vitro Antioxidant Evaluation of Mimosa pudica

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Authors

P. Muthukumaran
Meenakshi Chandrasekaran Arts and Science College, Dept. of Life Sciences, Pattukkottai-614626, Thanjavur, Tamilnadu, India
P. Shanmuganathan
Meenakshi Chandrasekaran Arts and Science College, Dept. of Life Sciences, Pattukkottai-614626, Thanjavur, Tamilnadu, India
C. Malathi
Meenakshi Chandrasekaran Arts and Science College, Dept. of Life Sciences, Pattukkottai-614626, Thanjavur, Tamilnadu, India

Abstract


The study of free radicals and antioxidants in biology is producing medical revolution that promises a new age of health and disease management. The present study was performed to evaluate the in vitro antioxidant effect of the ethanolic extract of Mimosa pudica (Mimosaceae) against free radical damage by different standard methods such as DPPH (1,1-diphenyl-2-picrylhydrazyl), Nitric Oxide (NO), ABTS (2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid)) and Hydrogen peroxide free radical model. The test extract exhibited significant inhibition in Nitric oxide and DPPH free radical formation with IC50 values of 78.1±1.75 and 35.00±1.15 μg/ml respectively. Whereas in the cases of ABTS and Hydrogen peroxide free radicals IC50 values of 81.00±3.85 and 449.60±2.55 μg/ml. Out of these four free radicals the extract showed potent activity on Nitric oxide and DPPH, which is compared to that of ascorbic acid and rutin taken as standards.