Asian Journal of Pharmaceutical Research

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Hantavirus Infection: An Overview


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1 Rajarambapu College of Pharmacy, Kasegaon (MS), India
     

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Hantavirus form an independent genus within Bunyaviridae family. Currently, there are >20 known sero/genotypes and several more are now being under examination. Each type of Hantavirus tends to be unique and specific to a particular host of rodents. In term of the target organs and severity of disease various forms of Hantaviruses are associated with a variety of disease. It recognises two major diseases: HPS and Haemorrhagic fever with renal syndrome (HFRS). Hantavirus is increasing throughout the world and new strains of Hantavirus have been progressively observed worldwide, which represents public health issues of rising global concern. The amount recognised virus types continue growing, and so does the spectrum of hanta virus disease. There is evidence in the British Isles of Hantavirus causing human disease, but at present it remains a mostly uncharacterized disease, due to its asymptomatic and non-specific mild infection and shortage of simple standardised laboratory diagnosis in hospital, Hanta viral infection may be underestimated, especially in developing countries. The present perception is outlined in this analysis on general properties, classification, laboratory diagnostics, treatment and prevention of Hantaviruses and hanta viral infection.


Keywords

Hantavirus, rodent, haemorrhagic fever, renal syndrome
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  • Nichol ST, Arikawa J, Kawaoka Y. Emerging viral diseases. ProcNatlAcadSci U S A. 2000; 97: 12411–2.

  • SchonrichG, Rang A, Luteke N, Raftery MJ, Charbonnel N, Ulrich RG. Hantavirus-induced immunity in rodent reservoirs and humans. Immunol Rev. 2008; 225: 163–89.

  • Zeier M, Handermann M, Bahr U, Rensch B, Muller S, Kehm R, et al. New ecological aspects of Hantavirus infection: a change of a paradigm and a challenge of prevention–a review. Virus Genes. 2005; 30: 157–80.

  • Plyusnin A, Morzunov SP. Virus evolution and genetic diversity of Hantaviruses and their rodent hosts. Curr Top MicrobiolImmunol. 2001; 256: 47–75.

  • Easterbrook JD, Klein SL. Immunological mechanisms mediating hantavirus persistence in rodent reservoirs. PLoSPathog. 2008; 23: 68-72.

  • Schmaljohn C, Hjelle B. Hantaviruses, a global disease problem. Emerg Infect Dis. 1997; 3: 95–104.

  • Johnson KM. Introduction. In: Lee HW, Calisher C, Schmaljohn, editors. Manual of hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Seoul (South Korea): WHO Collaborating Center for Virus Reference and Research (Hantaviruses), Asian Institute for Life Sciences; 1999: 1–6.

  • Zou Y, Xiao QY, Dng X, Lv W, Zhang SP, Li MH, et al. Genetic analysis of hantaviruses carried by Microtusfortis voles in China. Virus Res. 2008; 137: 122–8.

  • Chen HX, Qiu FX. Epidemiological surveillance on the hemorrhagic fever with renal syndrome in China. Chin Med J (Engl). 1993; 106: 857–63.

  • Zhang YZ, Xiao DL, Wang Y, Wang HX, Sun L, Tao XX, et al. The epidemic characteristics andpreventive measures of hemorrhagic fever with renal syndrome in China [in Chinese]. Zhonghua Liu Xing Bing XueZaZhi. 2004; 25: 466–9.

  • Arthur RR, Lofts RS, Gomez J, Glass GE, LeDuc JW, Childs JE (1992) Grouping of hantaviruses by small (s) genome segment polymerase chain reaction and amplification of viral RNA from wild-caught rats. Am J Trop Med Hyg 47: 210–224.

  • Avsic-Zupanc T, Xiao SY, Stojanovic R, Gligic A, van der Groen G, LeDuc JW (1992) Characterization of Dobrava virus: a hantavirus from Slovenia, Yugoslavia. J Med Virol 38: 132–13.

  • Bradford JR Nephritis in the British troops in Flanders Qland. J Med 9: 445–459.

  • Brummer-Korvenkontio M, Vahari A, von Bonsdorff CH, Vuorimies J, Manni T, Penttinen K, Oker-Blom N, Laehdvirta J (1980) Nephropathiaepidemica: detection of antigen in bank voles and serologic diagnosis of human infection. J Infect Dis. 1980; 141: 131–134.

  • Casals J, Henderson BE, Hoogstraal H, Johnson KM, Shelokov A (1970) A review of Soviet viral hemorrhagic fevers, J Infect Dis. 1969; 122: 437–453.

  • Childs JE, Korch GW, Glass GE, LeDuc JW, Shah KV (1987) Epizootiology of hantavirus infections in Baltimore: isolation of a virus from Norway rats, and characteristics of infected rat populations, Am J of Epi 126: 55–68.

  • Childs JE, Ksiazek TG, Spiropoulou CF, Krebs JW, Morzunov S, Maupin GO, Gage KL, Rollin PE, Sarisky J, Enscore RE, Frey JK, Peters CJ, Nichol ST (1994) Serologic and genetic identification of Peromyscusmaniculatus as the primary rodent reservoir for a new hantavirus in the southwestern United States. J Infect Dis 169: 1271–1280.

  • Cho HW, Howard CR Antibody responses in humans to an inactivated hantavirus vaccine (Hantavax). Vaccine. 1999; 17: 2569–2575.

  • Chu Y-K, Jennings G, Schmaljohn A, Elgh F, Hjelle B, Lee H-W, Jenison S, Ksiazek T, Peters CJ, Rollin P, Schmaljohn C. Cross- neutralization of hantaviruses with immune sera from experimentally infected animals and from hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome patients. J Infect Dis. 1995; 172: 1581–1584.

  • Crowley MR, Katz RW, Kessler R, Simpson SQ, Levy H, Hallin GW, Cappon J, Krahling JB, Wernly J. Successful treatment of adults with severe hantavirus pulmonary syndrome with extracorporeal membrane oxygenation. Crit Care Med F. 1998; 26: 409–414.

  • Kaukinen P, Vaheri A, Plyusnin A. Hantavirus nucleocapsid protein: A multifunctional molecule with both housekeeping and ambassadorial duties. Arch Virol 2005; 150: 1693-713.

  • Lundkvist A, Bjorsten S, Niklasson B, Ahlborg N. Mapping of B- cell determinants in the nucleocapsid protein of Puumala virus: Definition of epitopes specific for acute immunoglobulin G recognition in humans. ClinDiagn Lab Immunol. 1995; 2: 82-6.

  • McCaughey C, Hart CA. Hantaviruses. J Med Microbiol. 2000; 49: 587-99. Krüger DH, Ulrich R, Lundkvist AA. Hantavirus infections and their prevention. Microbes Infect. 2001; 3: 1129-44.

  • Jonsson CB, Hooper J, Mertz G. Treatment of hantavirus pulmonary syndrome. Antiviral Res. 2008; 78: 162-9.

  • Hjelle B, Goade D, Torrez-Martinez N, Lang-Williams M, Kim J, Harris RL, et al. Hantavirus pulmonary syndrome, renal insufficiency, and myositis associated with infection by Bayou hantavirus. Clin Infect Dis. 1996; 23: 495-500.

  • Enria DA, Briggiler AM, Pini N, Levis S. Clinical manifestations of new world hantaviruses. Curr Top MicrobiolImmunol. 2001; 256: 117-34.

  • Hjelle B, Goade D, Torrez-Martinez N, Lang-Williams M, Kim J, Harris RL, et al. Hantavirus pulmonary syndrome, renal insufficiency, and myositis associated with infection by Bayou hantavirus. Clin Infect Dis. 1996; 23: 495-500.

  • Bi Z, Formenty PB, Roth CE. Hantavirus infection: A review and global update. J Infect DevCtries 2008; 2: 3-23.

  • Chapman LE, Mertz GJ, Peters CJ, Jolson HM, Khan AS, Ksiazek TG, Koster FT, Baum KF, Rollin PE, Pavia AT, Holman RC, Christenson JC, Rubin PJ, Behrman RE, Bell LJ, Simpson GL, Sadek RF. Intravenous ribavirin for hantavirus pulmonary syndrome: safety andtolerance during 1 year of open-label experience. AntivirTher. 1999; 4: 211-219.

  • Sheela Thorat S. Gurunath Dadde S. Swapnali A. Mohite, Rohan Kumar R. Chavan, Mr. Ramling D Mali, Comparative Study of Antibacterial Activity of Tamarindus indica and Tagetes erecta, Research Journal of Pharmacognosy and Phytochemistry, 2019; 11(3): 186-188.

  • LoginovaSIa, Koval'chuk A V , Borisevich SV , KopylovaNK, PashchenkoIuI, Khamitov RA, Maksimov V A, Shuster AM. Antiviral effectiveness of the combined use of amixine andvirasole in experimental hemorrhagic fever with renal syndrome in sucking albino mice. VoprVirusol. 2005; 50: 30-32.

  • Plyusnin A., Mustonen J., Asikainen K., Plyusnina A., Niemimaa J., Henttonen H., Vaheri A. Analysis of puumala hantavirus genome in patients with nephropathiaepidemica and rodent carriers from the sites of infection. J Med Virol. 1999; 59: 397-405.

  • Kramski M, Meisel H, Klempa B, Krüger DH, Pauli G, Nitsche A. Detection and typing of human pathogenic hantaviruses by real- time revers transcription-PCR andpyrosequencing. Clin Chem. 2007; 53: 1899-905.

  • Biel SS, DonosoMantke O, Lemmer K, Vaheri A, Lundkvist A, Emmerich P , Hukic M, Niedrig M (2003) Quality control measures for the serological diagnosis of hantavirus infections. J ClinVirol 28: 248-256.

  • Kallio-Kokko H, Vapalahti O, Lundkvist A, Vaheri A. Evaluation of Puumala virus IgG and IgM enzyme immunoassays based on recombinant baculovirus- expressed nucleocapsid protein for early nephropathiaepidemica diagnosis. ClinDiagn Virol.1998;10:83-90.

  • Dhadde G.S, Yadav J.P., Sapate R.B, Mali H.S, Raut I.D, In vitro Anthelmintic Activity of crude extract of flowers of Bougainvillea Spectabilis Wild against Pheretima Posthuma, International Journal of Pharmacy and Pharmaceutical Research, 2020; 17: 1- 18.

  • Lundkvist A, Hukic M, Horling J, Gilljam M, Nichol S, Niklasson B (1997) Puumala and Dobrava viruses cause hemorrhagic fever with renal syndrome in Bosnia-Herzegovina: evidence of highly cross-neutralizing antibody responses in early patient sera. J Med Virol 53: 51-59.

  • Gibbs CJ Jr, Gajdusek DC, Yanagihara R. Serotypic classification of hantaviruses by indirect immunofluorescent antibody and plaque reduction neutralization tests. J Clin Microbiol. 1985; 22: 940-944.

  • Lee PW, 39. Tennstedt C, Wunschmann S, Schmitz H, Schreiber M. Pathological-anatomical findings after serologic and molecular biologic evidence of Hantaanvirus infection. Zentralbl Pathol. 1994; 140: 173-180.

  • Ahn C, Cho JT, Lee JG, Lim CS, Kim YY, Han JS, Kim S, Lee JS (2000) Detection of Hantaan and Seoul viruses by reverse transcriptase-polymerase chain reaction (RT-PCR) and restriction fragment length polymorphism (RFLP) in renal syndrome patients with hemorrhagicfever. ClinNephrol 53: 79-89.

  • Aitichou M, Saleh SS, McElroy AK, Schmaljohn C, Ibrahim MS. Identification ofDobrava, Hantaan, Seoul, and Puumala viruses by one-step real-time RT-PCR. J Virol Methods.2005; 124: 21-26.

  • Mills JN. Regulation of rodent-borne viruses in the natural host: implications for human disease. Arch VirolSuppl. 2005; 19: 45-57.

  • Dhadde Gurunath S.*, Mali Hanmant S., Sapate Rohit B., Vakhariya Rohan R., Raut Indrayani D., Nitalikar Manoj M., Investigation of In-Vitro Anthelmintic Activity of Methanolic Extract of Tylophora Indica Leaves Against Haemonchus Contortus, Journal of University of Shanghai for Science and Technology, 2021; 23(2): 37-42.

  • Glass GE, Johnson JS, Hodenbach GA, Disalvo CL, Peters CJ, Childs JE, Mills JN. Experimental evaluation of rodent exclusion methods to reduce hantavirus transmission to humans in rural housing. Am J Trop Med Hyg. 1997; 56: 359-364.


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  • Hantavirus Infection: An Overview

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Authors

Shid Shubangi J.
Rajarambapu College of Pharmacy, Kasegaon (MS), India
Sapate Rohit B.
Rajarambapu College of Pharmacy, Kasegaon (MS), India
Raut Indrayani D.
Rajarambapu College of Pharmacy, Kasegaon (MS), India
Dhadde Gurunath S.
Rajarambapu College of Pharmacy, Kasegaon (MS), India
Mali Hanmant S.
Rajarambapu College of Pharmacy, Kasegaon (MS), India
Joshi Saurabh
Rajarambapu College of Pharmacy, Kasegaon (MS), India
Shaikh Bilal
Rajarambapu College of Pharmacy, Kasegaon (MS), India

Abstract


Hantavirus form an independent genus within Bunyaviridae family. Currently, there are >20 known sero/genotypes and several more are now being under examination. Each type of Hantavirus tends to be unique and specific to a particular host of rodents. In term of the target organs and severity of disease various forms of Hantaviruses are associated with a variety of disease. It recognises two major diseases: HPS and Haemorrhagic fever with renal syndrome (HFRS). Hantavirus is increasing throughout the world and new strains of Hantavirus have been progressively observed worldwide, which represents public health issues of rising global concern. The amount recognised virus types continue growing, and so does the spectrum of hanta virus disease. There is evidence in the British Isles of Hantavirus causing human disease, but at present it remains a mostly uncharacterized disease, due to its asymptomatic and non-specific mild infection and shortage of simple standardised laboratory diagnosis in hospital, Hanta viral infection may be underestimated, especially in developing countries. The present perception is outlined in this analysis on general properties, classification, laboratory diagnostics, treatment and prevention of Hantaviruses and hanta viral infection.


Keywords


Hantavirus, rodent, haemorrhagic fever, renal syndrome

References