Asian Journal of Pharmaceutical Research

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Microwave Generated Bionanocomposites for Solubility and Dissolution Enhancement of Poorly Water Soluble Drug


Affiliations
1 Sri Sai College of Pharmacy, Badhani, Pathankot, Punjab., India
     

   Subscribe/Renew Journal


Drugs that shows complete oral absorption and good bioavailability are soluble in gastrointestinal tract or vice versa. Objective and Method: To enhance the solubility and dissolution of poorly water soluble drug itraconazole. Technique used- Microwave generated bionanocomposites technique. Carriers- Chitosan, &#946- cyclodextrin and Poly vinyl pyrolidine. Result and Conclusion: The prepared bionanocomposites was evaluated by UV spectroscopy, XRD study, In vitro drug release study and TEM. The results shows that in vitro data obtained for bionanocomposites of itraconazole showed increase solubility in phosphate buffer having pH= 6.8 and the method of preparation of itraconazole found to be simple, reproducible, provide good solubility and drug content. Also it is obtained that there was maximum 23 fold increase in solubility when Poly vinyl pyrolidine used as a carrier in 1:4 and hence considered as effective carrier for crystallization of itraconazole.


Keywords

Bionanocomposites, Nanocomposites, Itraconazole, polymer, solubility
Subscription Login to verify subscription
User
Notifications
Font Size


  • Nigal A, Darekar A, Saudagar R. A Review on Nanohybrids: Technique for Solubility Enhancement of Poorly Water Soluble Drugs. Journal of Drug Delivery and Therapeutics. 2019 May, 9(3), page no: 634-640.

  • Rabinow BE. Nanosuspensions in drug delivery. Nature reviews Drug discovery. 2004 Sep, 3(9), page no: 785-796.

  • Kadu PJ, Kushare SS, Thacker DD, Gattani SG. Enhancement of oral bioavailability of atorvastatin calcium by self-emulsifying drug delivery systems (SEDDS). Pharmaceutical Development and Technology. 2011 Feb, 16(1), page no: 65-74.

  • T. yasuhiro, M. Deanna. The biopharmaceutics classification system: sub classes for invivo predictive dissolution methodology and IVIVC. European Journal of Pharmaceutical Sciences. 2014 Jan, 57, page no: 1-47.

  • Baka E. Development and examination of solubility measurement methods for drug solubility determination (Doctoral dissertation, Semmelweis University).

  • Jouyban A, Fakhree MA. Experimental, computational methods pertaining to drug solubility. Toxicity and Drug testing. 2012 Feb, (1), page no: 187-213.

  • Ploehn HJ, Russel WB. Interactions between colloidal particles and soluble polymers. Advances in Chemical Engineering. 1990 Jan, 15, page no: 137-228.

  • A. deshmukh, K. tiwari. Solubility enhancement techniques for poorly water-soluble drugs. International Journal of Pharmaceutical Sciences and Nanotechnology. 2017 June, 10(3), page no: 3701-3708.

  • Y . thorat, I. gonjari. International journal of pharmaceutical sciences and research. 2011 sept, 2(10), page no: 2501-2513.

  • Ruiz-Hitzky E, Darder M, Aranda P. Functional biopolymer nanocomposites based on layered solids. Journal of Materials Chemistry. 2005 sept, 15(35-36), Page no: 3650-3662.

  • Shchipunov Y. Bionanocomposites: Green sustainable materials for the near future. Pure and Applied Chemistry. 2012 Oct, 84(12), page no: 2579-2607.

  • PP sambarkkar, SL patwekar. International journal of pharmacy and pharmaceutical sciences. 2012 jan, 4(2), page no: 60-65.

  • https://en.m.wikipedia.org/wiki/itraconazole

  • Takara K, Tanigawara Y, Komada F, Nishiguchi K, Sakaeda T, Okumura K: Cellular pharmacokinetic aspects of reversal effect of itraconazole on P-glycoprotein-mediated resistance of anticancer drugs. Biological Pharmaceutical Bulletin. 1999 Dec, 22(12), page no: 1355-1359.

  • Bhat MR. Microwave-generated bio-nanocomposites for Solubility Enhancement of Nifedipine. Asian Journal of Pharmaceutics (AJP). 2016 Dec, 10(04), page no: 1-9.

  • Pandey A and Rath B. Pharmaceutical Preformulation Studies with Special Emphasis on Excipients Compatibility Chem Inform. 2012 june, 43(23), page nio: 1029-1048.

  • Pavia DL, Lampman GM and Kriz GS. Introduction to Spectroscopy. Harcourt college publishers, Orlando, Florida, USA. 2015 aug, 5, page no 1-786.

  • Baka E, Comer JE and Takacs-Novak K. Study of equilibrium solubility measurement by saturation shake-flask method using hydrochlorothiazide as model compound. Journal of Pharmaceutical and Biomedical Analysis. 2008 feb, 46(2), page no: 335-341.

  • D. phanchaxari, K. sumit. Enhancement of solubility and dissolution property of griseofulvin by nanocrystallization. International Journal of Drug Development and Research. 2011 may, 3(2), page no: 180-191.

  • MR shivalingam, T. jyothibasu. Formulation and evaluation of solid dispersion of glipizide for dissolution rate enhancement. International Journal of Pharmaceutical Research and Development. 2011 mar, page no: 231-239.

  • Silva RD, Oliveira TA, Conceição ID, Araque LM, Alves TS, Barbosa R. Evaluation of hydrolytic degradation of bionanocomposites through fourier transform infrared spectroscopy. Polímeros. 2018 Sep, 28(4), page no: 348-354.

  • Bhat MR, Sharma S, Chimkode RM, Derkar GK, Sarla RM, Payghan SA. Optimization bio-nanocomposites of fenofibrate for enhancement of solubility and dissolution using microwave induced diffusion technique. International Journal of Applied Research in Science and Engineering, 2016 nov, page no: 209-216.

  • Patil AA, Payghan. Bionanocomposites: approach solubility and bioavailability and bioavailability enhancement of poorly water soluble drugs. International Journal of Universal Pharmacy and Biosciences. 2014 aug, 3(4), page no: 258-268.

  • Sonawane DD, Jat RK, Pawar AY. Development of microwave generated Nanocomposites for solubility enhancement of BCS class II drug. The Pharma Innovation Journal 2018, 7(12), page no: 270-277.

  • M. kale, A. pawar. International Journal of Chem Tech Research. 2018, 11(5), page no: 124-138.

  • Shaikh SA. Formulation and development of s-(-)-Amlodipine besylate tablets to improve the dissolution profile. Asian Journal of Pharmaceutics (AJP. 2016 Sep, 1(1), page no: 199-206.


Abstract Views: 110

PDF Views: 0




  • Microwave Generated Bionanocomposites for Solubility and Dissolution Enhancement of Poorly Water Soluble Drug

Abstract Views: 110  |  PDF Views: 0

Authors

Suxam
Sri Sai College of Pharmacy, Badhani, Pathankot, Punjab., India
Nitan Bharti
Sri Sai College of Pharmacy, Badhani, Pathankot, Punjab., India
Pooja Sharma
Sri Sai College of Pharmacy, Badhani, Pathankot, Punjab., India
Neha kumari
Sri Sai College of Pharmacy, Badhani, Pathankot, Punjab., India

Abstract


Drugs that shows complete oral absorption and good bioavailability are soluble in gastrointestinal tract or vice versa. Objective and Method: To enhance the solubility and dissolution of poorly water soluble drug itraconazole. Technique used- Microwave generated bionanocomposites technique. Carriers- Chitosan, &#946- cyclodextrin and Poly vinyl pyrolidine. Result and Conclusion: The prepared bionanocomposites was evaluated by UV spectroscopy, XRD study, In vitro drug release study and TEM. The results shows that in vitro data obtained for bionanocomposites of itraconazole showed increase solubility in phosphate buffer having pH= 6.8 and the method of preparation of itraconazole found to be simple, reproducible, provide good solubility and drug content. Also it is obtained that there was maximum 23 fold increase in solubility when Poly vinyl pyrolidine used as a carrier in 1:4 and hence considered as effective carrier for crystallization of itraconazole.


Keywords


Bionanocomposites, Nanocomposites, Itraconazole, polymer, solubility

References