Asian Journal of Pharmaceutical Research

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A Comprehensive Review on Targeted Drug Delivery System


Affiliations
1 Department of Pharmaceutics, Institute of Pharmacy, Angola, Turkey
     

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Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance. These routes provide promising alternatives to parenteral drug delivery particularly for peptide and protein therapeutics. For this purpose, several drug delivery systems have been formulated and are being investigated for nasal and pulmonary delivery. These include liposomes, proliposomes, microspheres, gels, prodrugs, and cyclodextrins, among others. Nanoparticles composed of biodegradable polymers show assurance in fulfilling the stringent requirements placed on these delivery systems, such as ability to be transferred into an aerosol, stability against forces generated during aerosolization, biocompatibility, targeting of specific sites or cell populations in the lung, release of the drug in a predetermined manner, and degradation within an acceptable period of time.


Keywords

Targeted Drug Delivery, Microspheres, Nanoparticles, Liposomes, Monoclonal antibodies
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  • A Comprehensive Review on Targeted Drug Delivery System

Abstract Views: 281  |  PDF Views: 0

Authors

Wajid Ahmad
Department of Pharmaceutics, Institute of Pharmacy, Angola, Turkey
Taimur Khan
Department of Pharmaceutics, Institute of Pharmacy, Angola, Turkey
Imran Basit
Department of Pharmaceutics, Institute of Pharmacy, Angola, Turkey
Javed Imran
Department of Pharmaceutics, Institute of Pharmacy, Angola, Turkey

Abstract


Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance. These routes provide promising alternatives to parenteral drug delivery particularly for peptide and protein therapeutics. For this purpose, several drug delivery systems have been formulated and are being investigated for nasal and pulmonary delivery. These include liposomes, proliposomes, microspheres, gels, prodrugs, and cyclodextrins, among others. Nanoparticles composed of biodegradable polymers show assurance in fulfilling the stringent requirements placed on these delivery systems, such as ability to be transferred into an aerosol, stability against forces generated during aerosolization, biocompatibility, targeting of specific sites or cell populations in the lung, release of the drug in a predetermined manner, and degradation within an acceptable period of time.


Keywords


Targeted Drug Delivery, Microspheres, Nanoparticles, Liposomes, Monoclonal antibodies

References