Asian Journal of Pharmaceutical Research

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Self-nano Emulsifying Drug Delivery System (SNEDDS): Future Aspects


Affiliations
1 Department of pharmaceutics, S.J. Thakkar Pharmacy College, Kalawad Road, Rajkot-360005. Gujarat, India
     

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Oral route is the easiest and most convenient route for drug administration. more than 40% of new chemical entities exhibit poor aqueous solubility, resulting in unsatisfactory oral drug delivery. The major problem in oral drug formulation is low erratic bioavailability. This may lead to high inter and intra variability lack of dose proportionality and therapeutic failure. For improvement of bioavailability of drug is one of the greatest challenges in drug formulation. Various technological strategies are reported in literature including solid dispersions, cyclodextrines complex formation or micronization and different technologies of drug delivery system. SNEDDS may be a promising strategy to improve the rate and extent of oral absorption. SNEDDS are mixture of oil, surfactant, solvents and cosolvents / surfactants. The principle characteristic of these systems in their ability to form oil-in-water (o/w) emulsion or micro emulsion upon mild agitation following dilution by an aqueous phase. The characterization of SNEDDS and application of SNEDDS is also introduced, with particular emphasis being placed on the developments of dosage form of SNEDDS.

Keywords

Self-nano Emulsifying Drug Delivery System, Solubility, Improvement of Bioavailability, Surfactant
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  • Robinson JR. Introduction: Semi-solid formulations for oral drug delivery. B T Gattefosse. 1996; 89:11-3.

  • Aungst BJ. Novel formulation strategies for improving oral bioaviliability of drugs with poor membrane permeation or presystemic metabolism. J. Pharma. Sci. 1993; 82: 979-986.

  • Gursoy RN, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother. 2004; 58: 173-182.

  • Khoo SM, Humberstone AJ, Porter CJ, Edwards GA, Charman WN. Formulation design and bioavailability assessment of lipidic self-emulsifying Formulations of Halofantrine. Int J of Pharm. 1998; 167: 155-164.

  • Charman SA, Charman WN, Rogge MC, Wilson TD, Pouton CW. Self-emulsifying drug delivery systems: formulation and biopharmaceutical evaluation of an investigational lipophilic compound. Pharm Res. 1992; 9: 87-93.

  • Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm. Res. 1995; 12: 1561- 1572.

  • Groves MJ, Mustafa RMA, Carless, JE. Phase studies of mixed phosphate surfactants, n-hexane and water. J. Pharm. Pharmacol. 1974; 26: 616-623.

  • Wakerly MG, Pouton CW, Meakin BJ, Morton FS. Self emulsification of vegetable oil-non-ionic surfactant mixtures. ACS Symp. Ser. 1986; 311: 242-255.

  • Nazzal S, Smalyukh II, Lavrentovich OD, Khan MA. Preparation and in vitro characterization of a eutectic based semisolid selfnanoemulsified drug delivery system (SNEDDS) of ubiquinone: mechanism and progress of emulsion formation. Int. J. Pharm. 2002; 235: 247–265.

  • Reiss H. Entropy-induced dispersion of bulk liquids. J. Colloids Interface Sci. 1975; 53: 61-70.

  • Patel J, Shah A. Self emulsifying delivery systems for poorly absorbed drugs. Int. J. Pharm. Sci. and Nano Tech. 2008; 1(2) : 123-128.

  • Patel PA, Chaulang GM. Self emulsifying drug delivery system. Research J. Pharm. and Tech. 2008; 1(4): 313-323.

  • Pouton CW. Formulation of self-emulsifying drug delivery systems. Adv Drug Delivery Rev. 1997; 25: 47-58.

  • Prajapati BG, Patel MM. Conventional and alternative pharmaceutical methods to improve oral bioavailability of lipophilic drugs. Asian journal of pharmaceutics. 2007; 1(1): 1-8.

  • Vergote GJ, Vervaet C, Van DI, Hoste S, Smedt DS, Demeester J, Jain RA, Ruddy S, Remon JP. An oral controlled release matrix pellet formulation containing nanocrystalline ketoprofen. Int J Pharm. 2001; 219(1): 81-87.

  • Kim HJ, Yoon KA, Hahn M, Park ES, Chi SC. Preparation and In Vitro Evaluation of Self- Microemulsifying Drug Delivery Systems Containing Idebenone. Drug Dev. and Ind.Pharm. 2000; 26(5): 523-529.

  • Dixit RP, Nagarsenker MS. Formulation and in vivo evaluation of self-nanoemulsifying granules for oral delivery of a combination of ezetimibe and simvastatin. Drug Dev. Ind. Pharm.2008; 34: 1285–1296.

  • Pouton CW. Effects of the inclusion of a model drug on the performance of self-emulsifying formulations. J. Pharma. Pharmacol. 1985; 37: 1.

  • Anton N, Benoit JP, Saulnier P. Design and production of nanoparticles formulated from nano-emulsion templates. J. Control. Release. 2008; 128: 185–199.

  • Bouchemal K, Briançon S, Perrier E, Fessi H. Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimisation. Int. J. Pharm. 2004; 280: 241–251.

  • Pouton CW, Porter CJ. Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Adv. Drug Deliv. Rev. 2008; 60(6): 625–637.

  • Sadurni N, Solans C, Azemar N, Garcia-Celma MJ. Studies on the formation of O/W nano-emulsions, by low-energy emulsification methods, suitable for pharmaceutical applications. Eur.J.Pharm. Sci. 2005; 26: 438–445.

  • Anton N, Vandamme TF. The universality of low-energy nanoemulsification. Int. J. Pharm. 2009; 377: 142–147.

  • Jumaa M, Muller BW. Formulating and stability of benzodiazepines in a new lipid emulsion formulation. Pharmazie. 2002; 57: 740–743.

  • Strickley RG. Solubilizing excipients in oral and injectable formulations. Pharm. Res.2004; 21: 201–230.

  • Date AA, Nagarsenker MS. Parenteral microemulsions: an overview. Int. J. Pharm.2008; 355: 19–30.

  • Date AA, Nagarsenker MS. Design and evaluation of selfnanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil. Int. J. Pharm. 2007; 329: 166–172.

  • Wang L, Dong J, Chen J, Eastoe J, Li X. Design and optimization of a new self-nanoemulsifying drug delivery system. J. Colloid Interface Sci. 2009; 330: 443–448.

  • Basalious EB, Shawky N, Badr-Eldin SM. SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: development and optimization. Int. J. Pharm. 2010; 391: 203–211.

  • Rege BD, Kao J, Pollia J. Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers. Eur. J. Pharm. Sci. 2002; 16: 237–246.

  • Mountfield RJ, Senepin S, Schleimer M, Walter I, Bittner B. Potential inhibitory effects of formulation ingredients on intestinal cytochrome P450. Int. J. Pharm. 2000; 211: 89–92.

  • Hugger ED, Novak BL, Burton PS, Audus KL, Borchardt RT. A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit p-glycoprotein activity in vitro. J. Pharm. Sci. 2002; 91: 1991–2002.

  • Tije AJ, Verweij J, Loos WJ. Pharmacological effects of formulation vehicles implications for cancer chemotherapy. Clin. Pharmacokinet. 2003; 42: 665–685.

  • Ren F, Jing Q, Cui J, Chen J, Shen Y. Self-Nanoemulsifying drug delivery system (SNEDDS) of anethole trithione by combined use of surfactants. J. Disp. Sci. Tech. 2009; 30: 664–670.

  • Yoo JH, Shanmugam S, Thapa P. Novel self-nanoemulsifying drug delivery system for enhanced solubility and dissolution of lutein. Arch. Pharm. Res. 2010; 33: 417–426.

  • Strickley RG. Solubilizing excipients in oral and injectable formulations. Pharm. Res. 2004; 21: 201–230.

  • Morais JM, Santos O, Delicato T, Rocha-Filho P. Characterization and evaluation of electrolyte influence on canola oil/water nanoemulsion. J. Disp. Sci. Tech. 2006; 27: 1009–1014.

  • Attama AA, Nkemnele MO. In vitro evaluation of drug release from self micro-emulsifying drug delivery systems using a biodegradable homo lipid from Capra hircus. Int. J. Pharm. 2005; 304: 4–10.

  • Hu YX. Preparation and evaluation of 5-FU/PLGA/gene nanoparticles. Key Eng. Mat.2005; 288–289: 147-150.

  • Trickler WJ. A novel nanoparticle formulation for sustained paclitaxel delivery. AAPS Pharm. Sci. Tech., 2008; 10: 486-493.

  • Mahmoud EA, Bendas ER, Mohamed MI. Preparation and Evaluation of Self-nanoemulsifying Tablets of Carvedilol. AAPS Pharm Sci. Tech. 2009; 10(1): 183-192.

  • Suresh PK, Sharma S. Formulation and in-vitro characterization of self-nanoemulsifying drug delivery system of cinnarizine. Pharmacie Globale. 2011; 9(08): 1-6.

  • Patil PR, Biradar SV, Paradkar AR. Extended Release Felodipine Self-Nanoemulsifying System. AAPS Pharm Sci. Tech. 2009; 10(2): 515-523.

  • Yosra SR, El-Massik MA, Abdallah OY. Self-nanoemulsifying drug delivery systems of tamoxifen citrate: Design and optimization. Int.J.Pharma. 2009; 380: 133–141.

  • Nielsen FS, Gibaulte LW. Characterization of prototype selfnanoemulsifying formulation of lipophilic compounds. J.Pharm. Sci. 2007; 96: 876-892.

  • Taha EI, Al-Saidan S, Samy AM, Khan MA. Preparation and in vitro characterization of self-nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate. Int. J.Pharm. 2004; 285: 109–119.

  • Shafiq S, Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur. J. Pharm. Biopharm. 2007; 66: 227–243.

  • Patil P, Joshij, Paradkar P. Effect of formulatiuon variables on preparation and evaluation of gelled self-emulsifying drug delivery system(SEDDS)of ketoprofen. AAPS Pharm Sci Tech. 2004; 5(3): 34-42.

  • Patil P, Vandana P, Paradkar P. Formulation of selfemulsifying drug delivery system for oral delivery of simvastatin:In vitro and in vivo evaluation. Acta pharma. 2007; 57: 111-122.

  • Humberstone AJ, Charman WN. Lipid-based vehicles for the oral delivery of poorly water soluble drugs. Adv Drug Del Rev. 1997; 25: 103-28.

  • Charman WN, Porter CJ, Mithani S, Dressman JB. Physiochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH. J Pharm Sci. 1997; 86: 269-82.


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  • Self-nano Emulsifying Drug Delivery System (SNEDDS): Future Aspects

Abstract Views: 2436  |  PDF Views: 7

Authors

Hiral A. Makadia
Department of pharmaceutics, S.J. Thakkar Pharmacy College, Kalawad Road, Rajkot-360005. Gujarat, India
Ami Y. Bhatt
Department of pharmaceutics, S.J. Thakkar Pharmacy College, Kalawad Road, Rajkot-360005. Gujarat, India
Ramesh B. Parmar
Department of pharmaceutics, S.J. Thakkar Pharmacy College, Kalawad Road, Rajkot-360005. Gujarat, India
Jalpa S. Paun
Department of pharmaceutics, S.J. Thakkar Pharmacy College, Kalawad Road, Rajkot-360005. Gujarat, India
H. M. Tank
Department of pharmaceutics, S.J. Thakkar Pharmacy College, Kalawad Road, Rajkot-360005. Gujarat, India

Abstract


Oral route is the easiest and most convenient route for drug administration. more than 40% of new chemical entities exhibit poor aqueous solubility, resulting in unsatisfactory oral drug delivery. The major problem in oral drug formulation is low erratic bioavailability. This may lead to high inter and intra variability lack of dose proportionality and therapeutic failure. For improvement of bioavailability of drug is one of the greatest challenges in drug formulation. Various technological strategies are reported in literature including solid dispersions, cyclodextrines complex formation or micronization and different technologies of drug delivery system. SNEDDS may be a promising strategy to improve the rate and extent of oral absorption. SNEDDS are mixture of oil, surfactant, solvents and cosolvents / surfactants. The principle characteristic of these systems in their ability to form oil-in-water (o/w) emulsion or micro emulsion upon mild agitation following dilution by an aqueous phase. The characterization of SNEDDS and application of SNEDDS is also introduced, with particular emphasis being placed on the developments of dosage form of SNEDDS.

Keywords


Self-nano Emulsifying Drug Delivery System, Solubility, Improvement of Bioavailability, Surfactant

References