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Daily Consumption of Antioxidants:-Prevention of Disease is better than Cure


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1 Department of Quality Assurance, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India
     

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Our life is threatened and unstable due to oxidative stress produced by a large population, pollution, economy, unhygenic sorrounding, insufficient intake of functional food, dietary supplements and nutraceuticals. Majority of population in india is suffered by unaffordable cost, poor economy and regular tension. Smoking,drugs,illness,even exercise can increase exposure to free radicals thus it contributes to oxidative stress,individual assessment of succeptibility becomes important.High altitude exposure results in decrease oxygen pressure and increased formation of reactive oxygen and nitrogen species. Oxidative stress leads to cause of several disease as diabetes, cancer, atherosclerosis, rheumatism, myocardial infaraction, hypertension etc. Antioxidants are abundant in vegetables and fruits and are also found in grain cereals, teas, legumes, and nuts. Antioxidants are our first line defense against free radical damage and critical for maintaining optimum health and well being. This review describes sources of free radical generation, causes of different disease,damage to DNA by free radicals,role of antioxidant in prevention of disease, antioxidants in normal physiological function, uses of antioxidants in treating cancer,diabetes, hypertension, rheumatoidarthritis,alzheimer,parkinson disease and ageing.

Keywords

Antioxidants, Freeradicals, Cancer, Diabetes, Ageing
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  • International project on Innovative nuclear reactors and fuel cycles- Action plan for 2012-2013.
  • The Growing Danger of Non-Communicable Diseases: Acting Now to Reverse Course, sept2011.
  • , Mitchell Kanter, Free Radicals, Exercise and antioxidant supplementation the Quaker oats company, 617 W main street, Barrington, Illinosis, 60010 USA, proceedings of the nutrition society(1998),57, 9-13.
  • Kenneth A Conklin, Jonsson, Free Radicals:- The Pros and Cons of Antioxidants; Comprehensive cancer centre, UCLA, Los Angeles, CA 90095-1778. American society for nutritional sciences. J.Nutr.134:3201-3204, 2004.
  • Ye Feng and Xiaochuan Wang, Review article on Antioxidant Therapies for Alzheimer’s Disease, Hindawi publishing corporation Oxidative medicine and cellular longevity vol-2012, article 17 pgs.
  • Gilberto Perez Trueba, Gregorio Martinez Sanchez, Atiliaguiliani. Oxygen Free Radical and Antioxidant Defense Mechanism in Cancer. Frontier in Bioscience 9, 2029-2044, September 1, 2004.
  • G.B. Kavishankar, N. Laxmidevi, S. Mahadeva Murthy, H.S. Prakash, S.R. Niranjana. A review article on Diabetes and Medicinal Plants, Int J Pharm Biomed sci 2011,2(3), 65-80
  • Lien Ai Pham-Huy, Hua He, Chuong Pham-Huy, Review article on Free Radicals, Antioxidants in Disease and Health; Faculty of Pharmacy, University of Paris 5, Paris, France.
  • Marian Valko, DieterLeibfritz, Jan Moncola, Mark T.D. Cronin, Milan Mazura, Joshua Telser, Free radicals and antioxidants in normal physiological functions and human disease, The International Journal of Biochemistry & Cell Biology 39 (2007) 44–84.
  • Rasikh Javaid, Mohd Aslam, Qudsia Nizami, Raheela Javaid, Role of Antioxidant Herbal Drugs in Renal Disorders: An Overview. Vol. 2 / Issue 1 / Jan-Mar, 2012.
  • Anil Mahajan, Vishal R Tandon , A Review on Antioxidants and Rheumatoid Arthritis. J Indian Rheumatol Assoc 2004 : 12 : 139 – 142.
  • RG Shiva Manjunath, Role of Antioxidants as an adjunct in periodontal therapy. India Journal of Academy of Advanced Dental Research, Vol 2; Issue 2: May 2011.
  • Antioxidants by Dr. Mark Percival Nut031 1/96 Rev. 10/98clinical Nutrition Insights Copyright © 1996 Advanced Nutrition Publications, Inc., Revised 1998.
  • Sanjiv A, Rao A, “ Tomatoe Lycophene and its Role in Human health and Chronic diseases.”CMAJ 163: 739-744, 2000.
  • Shindo Y, Witt E, Han D, et al. Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin. J Invest Dermatol 102(1):122-4 (1994 Jan).
  • Vivek Kumar Gupta and Surendra Kumar Sharma, Plants as Natural Antioxidants. Natural product Radiance Vol.5(4) 2006,pp 326-334.
  • The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group (The ATBC Study Group). 1994. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 330:1029–1035.
  • Clark L.C., B. Dalkin, A. Krongrad, G.F. Combs Jr., B.W. Turnbull, E.H. Slate, R. Witherington, J.H. Herlong, E. Janosko, D. Carpenter, C. Borosso, S. Falk, and J. Rounder. 1998. Decreased incidence of prostate cancer with selenium supplementation: Results of a doubleblind cancer prevention trial. Br. J. Urol. 81:730–734.
  • Singh RP, Sharad S, Kapur S. Free radicals and oxidative stress in neurodegenerative diseases: Relevance of Dietary Antioxidants. JIACM, 2004; 5:218-25.
  • Sies, H. et al., Antioxidant Function of Vitamins. Ann NY AcadSci 1992; 669:7-20.
  • Halliwell, B. Free Radicals, Antioxidants, and Human Disease: Curiosity, Cause, or Consequence. Lancet1994; 344:721-724.
  • Ames, B. Forward p. xix-xxv, in Natural Antioxidants in Human Health and Disease, ed. Frei,B. Academic Press: San Diego 1994.
  • Shweta K. Gediya, Rajan B. Mistry, Urvashi K. Patel, M. Blessy and Hitesh N. Jain, Herbal Plants: Used as a cosmetics. J. Nat. Prod. Plant Resour, 2011, 1 (1): 24-32.
  • Prashant L Kole, Hemant R Jadhav, Prasad Thakurdesai, Anantha Naik Naggapa , Cosmetics potential of herbal extracts, Pharmacy group, Birla institute of technology and science, Pilani- 333031, Rajasthan, India.
  • The British Herbal Pharmacopoeia, British Herbal Medicine Association, 1996.
  • Ceres A, The healing power of Herbal teas, Thorsons Publishers, London 1984.
  • Krishnamurthy K.H, Ayurvedic technical studies and herbal cosmetics of ancient india. Vedams Book (Pvt. Ltd), New Delhi 2001.
  • Anticancer Structure activity relationship of Semi synthetic analogues of Nor dihydro Guaiaretic acid by Ross Owen Meyers Copyright © Ross Owen Meyers 2005.
  • Michael A. Weiner, Ph.D. Herbal Antioxidants in Clinical Practice.The Journal of Orthomolecular Medicine Vol. 9, No.3, 1994.
  • Thomas JA. Oxidative stress, oxidant defense, and dietary constituents. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.; 1994:501-512.
  • 32.33,34,35,36,37. Robert A Jacob. Phd. Diabetes Self Management Article Updated October 2011.
  • Natural Herbal Remedies & Antioxidant Vitamin Wonders On http://www.free-ebooks-canada.com .
  • Lueng AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. Second Edition. New York, NY: Wiley & Sons, 1996.
  • Blumenthal M, et. al. ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council, 1998.
  • British Herbal Pharmacopoeia (1996). Fourth Edition.British Herbal Medicine Association Scientific Committee, West Yorks, England.
  • , 43.V. Kapoor, A review article on herbal cosmetics for skin and hair care National botanical research institute, Lucknow- 226001, Uttar Pradesh, India.
  • Amit Kunwar and K.I. Priyadarsini, Free radicals, oxidative stress and importance of antioxidants in human health, Radiation and photochemistry Division, Bhaba Atomic Research Centre, Trombay, Mumbai- 400085, India.
  • Das, U.N: A radical approach to cancer. Med SciMonit8, 79-92 (2002).
  • Dr. T Bahorun, MA Soobrattee, V Luximon-Ramma, OI Aruoma. Free Radicals and Antioxidants in Cardiovascular Health and Disease. Internet Journal of Medical Update, Vol. 1, No. 2, Jul-Dec 2006.
  • BayaniUttara, Ajay V. Singh, Paolo Zamboni, and R.T Mahajan. Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options.
  • Hoshino Y, Mishima M. Antioxidants & Redox signaling redox-based therapeutics for lung diseases. Antioxid Redox Signal. 2008;10:701-4.
  • Karatas F, Ozates I, Canatan H, et al. Antioxidant status and lipid peroxidation in patients with rheumatoid arthritis. Indian J Med Res 2003; 118: 178-181.
  • Singh RP, Shukla KP, Panday BL, Singh RG, Usha Singh RH. Recent approach in clinical experimental evaluation of diuretic action of punarnava (Boerhaavia diffusa) with special reference to nephriticsyndrome. Journal of Research and Education in Indian medicines. 1992;11(1):29-36.
  • The Standard – An concise update of important issues concerning natural health ingredients Vol-2, pgno.1, 1999 edited by Thomas. G. Gulliams Ph.D.
  • Ashok Agarwal, Sajal Gupta and Suresh Sikka, The role of free radicals and antioxidants in reproduction, Current Opinion in Obstetrics and Gynecology 2006, 18:325–332.
  • Chapple IL. Role of free radicals and antioxidants in the pathogenesis of the inflammatory periodontal diseases. ClinMolPathol1996;49:247- 255.
  • A. A. Hamid, O. O. Aiyelaagbe, L. A. Usman, O. M. Ameen and A. Lawal, African Journal of Pure and Applied Chemistry Vol. 4(8), pp. 142-151, August 2010.
  • Conklin, K. A. (2000) Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects. Nutr. Can. 37: 1–18.
  • Wadkar KA, Magdum CS, Patil SS, Naikwade NS. Antidiabetic potential and Indian medicinal plants. J Herbal Med and Toxicol 2008, 2, 45-50.
  • Simon R. J. Maxwell & Gregory Y. H. Lip, Free radicals and antioxidants in cardiovascular disease, Br J ClinPharmacol1997; 44: 307–317.
  • Irena I Kostova, Lanthanides as anticancer agents, current medicinal chemistry anticancer agents 5(6): 591-602 (2005).
  • P. K. J. P. D. Wanasundara and F. Shahidi, Antioxidants: Science, Technology, and Applications.
  • Nabil S. Kamel, MB, BCh, Julie Gammack, MD, Oscar Cepeda, MD, Joseph H. Flaherty, MD, Antioxidants and hormones as antiaging therapies: Cleveland Clinic Journal Of Medicine Volume 73,No. 12 December 2006, 1049-1058.
  • Dr. Linda Miles L. Ac., D.O.M., Natural Skincare Expert, The Secret to Anti-Aging? Antioxidants. derma e® Natural Bodycare,4485 Runway Street, Simi Valley, CA 93063. 805.582.2710. 800.521.3342, www.dermae.com © 2008.
  • Kanti Bhooshan Pandey, Syed Ibrahim Rizvi, Biomarkers OF Oxidative Stress in Red Blood Cells. Biomed Pap Med Fac UnivPalacky Olomouc Czech Repub. 2011 Jun; 155(2):131–136. DOI 10.5507/bp.2011.027.
  • Chandrashekhar D. Kamat, SunyanaGadal, Molina Mhatre, Kelly S. Williamson, Quentin N. Pye, and Kenneth Hensley, Antioxidants in Central Nervous System Diseases: Preclinical Promise and Translational Challenges, J Alzheimers Dis. 2008 November; 15(3): 473- 493.

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  • Daily Consumption of Antioxidants:-Prevention of Disease is better than Cure

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Authors

S Jadhav Sameer
Department of Quality Assurance, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India
R Salunkhe Vijay
Department of Quality Assurance, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India
S Magdum Chandrakant
Department of Quality Assurance, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India

Abstract


Our life is threatened and unstable due to oxidative stress produced by a large population, pollution, economy, unhygenic sorrounding, insufficient intake of functional food, dietary supplements and nutraceuticals. Majority of population in india is suffered by unaffordable cost, poor economy and regular tension. Smoking,drugs,illness,even exercise can increase exposure to free radicals thus it contributes to oxidative stress,individual assessment of succeptibility becomes important.High altitude exposure results in decrease oxygen pressure and increased formation of reactive oxygen and nitrogen species. Oxidative stress leads to cause of several disease as diabetes, cancer, atherosclerosis, rheumatism, myocardial infaraction, hypertension etc. Antioxidants are abundant in vegetables and fruits and are also found in grain cereals, teas, legumes, and nuts. Antioxidants are our first line defense against free radical damage and critical for maintaining optimum health and well being. This review describes sources of free radical generation, causes of different disease,damage to DNA by free radicals,role of antioxidant in prevention of disease, antioxidants in normal physiological function, uses of antioxidants in treating cancer,diabetes, hypertension, rheumatoidarthritis,alzheimer,parkinson disease and ageing.

Keywords


Antioxidants, Freeradicals, Cancer, Diabetes, Ageing

References