An Overview on Trends and Developments in Liposome-As Drug Delivery System

Liposomes, spherical vesicles consisting of one or more phospholipids bilayers, were first described in mid 60s by Banghum and coworkers. Since then, liposomes have made their way to the market. Liposomes are highly versatile structures for researcher's therapeutic and analytical applications. The insight gained from clinical use of liposome drug delivery systems can now be integrated to design liposomes targeted to tissues and cells with or without expression of target recognition molecules on liposomes membranes. Enhanced safety and heightened efficacy have been achieved for wide range of drug classes, including antitumor agents, antiviral, antifungal, antimicrobial, vaccines and gene therapeutics. This review summaries exclusively scalable industrial method of preparation of liposomes, marketed preparation of liposomes and analysis of liposomes. An additional point of view was taken to regulatory concerning liposomal drug formulations based on FDA and EMEA documents.