Development and Evaluation of Nanogel as a Carrier for Transdermal Delivery of Aceclofenac

The aim of the present study is to formulate nanosized dispersion of aceclofenac by emulsion-solvent diffusion method and then incorporate it into a gelling agent to produce nanogel. The formulations are characterized for the particle size and found to be below 400 nm. The drug content in the formulations was found satisfactory. DSC and FTIR analysis was performed to ensure the compatibility of the drug and excipients. The optimization was carried out by using factorial design and the formulations are characterized for in vitro drug diffusion, skin permeability, rheological properties and in vivo animal study. The in vivo animal studies showed significant improvement in the activity for the formulation in comparison with the conventional formulation. The formulation showed optimal permeability properties, stability and possessed a sustained drug release during the study period. The nanogel formulation showed the promising alternative to oral administration for aceclofenac.