Anti-Inflammatory and Analgesic Influence of Aqueous Leaf Extract of Commicarpus chinensis

Aim: To evaluate the anti-inflammatory and analgesic influence of aqueous leaf extract of Commicarpus chinensis.

Material and method: Wistar albino rats (180-200g) and Swiss albino mice (18-22g) of either sex were used for the study. The plants were collected from campus of Gulbarga University, Gulbarga, Karnataka and authenticated by department of botany, Gulbarga University. The plants were shade dried and subjected to soxhlet extraction using water as solvent. The aqueous extract in doses 100mg/Kg and 200mg/Kg were evaluated for anti-inflammatory and analgesic activities using carrageenan induced paw edema and acetic acid induced writhing models.

Results: The results were interpreted using one way ANOVA followed by Dunnett's test. The aqueous leaf extract of C.chinensis showed significant reduction in acute inflammation by reducing the volume in paw edema in rats and in peripheral algesia number of writhing are reduced significantly in mice in a dose dependent manner on comparison with the standard drugs.

Conclusion: C.chinensis is found to be an effective anti-inflammatory and analgesic agent because of the presence of flavonoids, saponins, tannins imparting antioxidant property to it.