Study of Bioactive Potential of Sponge Associated Microbes

Sponges are the commonest photosynthesizing host organisms in waters with relatively poor supplies of food particle. The sponges contain the bioactive compounds that have potential medical importance. In the present study, the potent antibacterial extra cellular products were isolated from endosymbionts. The isolates showed inhibitory interactions with various gram positive and negative bacteria. The antibacterial activity of the sponge extract was determined for 5 species of gram positive bacteria Acetobacter pasteuriances, Bacillus subtilis, Lactobacillus acidophilus, Klebsiella species, Lactococcus lactis and 2 species of gram negative bacteria Proteus vulgaris, Pseudomonas fluorescence. The extract of Sigmadocia medussa contained potential antibacterial agents. The maximum inhibition zone was produced by the extract against gram positive bacteria, Lactobacillus acidophilus was found to be 1.10cm and gram negative bacteria, and Pseudomonas fluorescence was found to be 2.30cm. The true bacterial endo-symbionts may SES1- SES10 influence the synthesis of secondary metabolites of the host Sigmadocia medussa.