Nanosuspension: An Emerging Trend for Bioavailability Enhancement of Poorly Soluble Drugs

Drug effectiveness is influenced by a crucial factor like solubility of drug, independence of the route of administration. Most of the newly discovered drugs coming out from High-throughput screening are failing due to their poor water solubility which is major problem for dosage form design. Now a day, nanoscale systems for drug delivery have gained much interest as a way to improve the solubility problems. Nanosuspension technology is a unique and economical approach to overcome poor bioavailability that is related with the delivery of hydrophobic drugs, including those that are poorly soluble in aqueous media. Design and development of nanosuspension of such drugs is an attractive alternative to solve this problem. Preparation of nanosuspension is simple and applicable to all poorly soluble drugs. A nanosuspension not only solves the problem of solubility and bioavailability but also alters pharmacokinetic profile of the drug which may also improve safety and efficacy. This review article takes account of introduction, advantages, properties, formulation consideration, preparation, characterization and application of the nanosuspensions.