Development and Characterization of Perindopril Erbumine Loaded Proniosomal Gel

The present work deals with the preparation of perindopril erbumine proniosomal gel by coaservation phase separation method by using different surfactants in different ratios. The prepared proniosomal formulation were evaluated for Vesicle size analysis, Surface morphological studies, Rate of spontaneity, encapsulation efficiency, In vitro release Stability studies kinetic data analysis. The vesicle of proniosome varied between 15.13±4.65μm to24.05±2.10μm (without agitation) from 4.65±5.89μm to 9.7±0.15μm (with agitation), Rate of spontaneity between 9.10±0.65mm³×1000 to 15.26±5.35mm³×1000, % encapsulation efficiency between 70.72±0.39% to 76.43±5.56%. In vitro release profile indicated that, increases in liphophilicity of surfactants decreases release of perindopril erbumine from proniosomal formulations. Among the various formulation studied, proniosomal gel with T20:T60 in ratio of 900:100showed the highest % of drug release (80.03%) over period of 24 hrs. Cumulative amount of drug permeated through rat abdominal skin for optimized formulation was found to be 75.263%. The mechanism of drug release was Non-Fickin diffusion controlled zero order kinetics for optimized formulations PNG3, PNG6, PNG9, PNG12. Stability studies indicated that, the prepared proniosomal gel remained more stable at room refrigeration temperature than oven temperature.