Formulation and In Vitro Evaluation of Glipizide as Floating Drug Delivery System

The purpose of this investigation was to prepare a gastro retentive drug delivery system of Glipizide. Floating tablets of Glipizide were prepared employing different polymers like HPMC K100M, sodium alginate, Carbopol 940, and PVP K30 by effervescent technique. Sodium bicarbonate and citric acid were incorporated as a gas generating agent. The Floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy, swelling study, dissolution studies and stability studies. The drug release profile and floating properties was investigated. The prepared tablets exhibited satisfactory physico-chemical characteristics. All the prepared batches showed good in vitro buoyancy. The tablet swelled radially and axially during in vitro buoyancy studies. It was observed that the tablet remained buoyant for 16-24 hours. Stability studies were performed on the promising formulations at 40±2° C with 75±2 RH for 3 months.