Asian Journal of Pharmacy and Technology

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Review Article:Solubility Enhancement by Solid Dispersion


Affiliations
1 Department of Pharmaceutics, R.G. Sapkal college of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
2 Department of Pharmaceutical Chemistry, R.G. Sapkal college of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
     

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Enhancement of solubility, dissolution rate and bioavailability of drug is a very challenging task in drug development, nearly 40% of the new chemical entities currently being discovered are poorly water soluble drugs. The solubility behavior of the drugs remain one of the most challenging aspects in formulation development. This results in important products not reaching the market or not achieving their full potential. Solid dispersion is one of the techniques adopted for the formulation of such drugs and various methods are used for the preparation of solid dispersion. Solid dispersion is generally prepared with drug which is having poor aqueous solubility and hydrophilic carrier. This article review various methods and concept of solid dispersion, criteria for drug selection, advantage and disadvantage, characterization, and application.
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Abstract Views: 328

PDF Views: 6




  • Review Article:Solubility Enhancement by Solid Dispersion

Abstract Views: 328  |  PDF Views: 6

Authors

D. M. Shinkar
Department of Pharmaceutics, R.G. Sapkal college of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
A. N. Patil
Department of Pharmaceutics, R.G. Sapkal college of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
R. B. Saudagar
Department of Pharmaceutical Chemistry, R.G. Sapkal college of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

Abstract


Enhancement of solubility, dissolution rate and bioavailability of drug is a very challenging task in drug development, nearly 40% of the new chemical entities currently being discovered are poorly water soluble drugs. The solubility behavior of the drugs remain one of the most challenging aspects in formulation development. This results in important products not reaching the market or not achieving their full potential. Solid dispersion is one of the techniques adopted for the formulation of such drugs and various methods are used for the preparation of solid dispersion. Solid dispersion is generally prepared with drug which is having poor aqueous solubility and hydrophilic carrier. This article review various methods and concept of solid dispersion, criteria for drug selection, advantage and disadvantage, characterization, and application.